ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) (C-Term), (AA 718-746) antibody

Details for Product No. ABIN390062
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Antigen
Synonyms CG7955, Dmel\\CG7955, dABCB7, GB11034, ABCB7, fc20c02, wu:fc20c02, ABC7, ASAT, Atm1p, EST140535, AA517758, AU019072, Abc7
Epitope
C-Term, AA 718-746
(14), (3), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(43), (15), (15), (12), (12)
Host
Rabbit
(44)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(27), (21), (17), (11), (10), (2), (2)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN390062
291.50 $
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Immunogen This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-746 AA from the C-terminal region of human ABCB7.
Clone RB1811
Isotype Ig
Specificity This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723~752 amino acids from the C-terminal region of human ABCB7.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ABCB7
Background The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
Molecular Weight 82641 DA
Gene ID 22
NCBI Accession NP_004290
Research Area Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) (C-Term), (AA 718-746) antibody The anti-ABCB7 C-term Pab (ABIN390062) is used in Western blot to detect ABCB7 in Jurkat cell lysate.
anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) (C-Term), (AA 718-746) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Allikmets, Raskind, Hutchinson et al.: "Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)." in: Human molecular genetics, Vol. 8, Issue 5, pp. 743-9, 1999 (PubMed).

Csere, Lill, Kispal: "Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p." in: FEBS letters, Vol. 441, Issue 2, pp. 266-70, 1999 (PubMed).

Mao, Fu, Wu et al.: "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 14, pp. 8175-80, 1998 (PubMed).

Shimada, Okuno, Kawai et al.: "Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia." in: Journal of human genetics, Vol. 43, Issue 2, pp. 115-22, 1998 (PubMed).

Savary, Allikmets, Denizot et al.: "Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human." in: Genomics, Vol. 41, Issue 2, pp. 275-8, 1997 (PubMed).

Validation Images
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