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Melanoma Antigen Family A, 2 (MAGEA2) (N-Term), (AA 81-108) antibody

Details for Product No. ABIN390106
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Antigen
Epitope
N-Term, AA 81-108
(9), (2)
Reactivity
Human
(28)
Host
Rabbit
(27), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(17), (10), (9), (6), (6)
Pubmed 4 references available
Quantity 400 µL
Options
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Catalog No. ABIN390106
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Immunogen This MAGEA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 AA from the N-terminal region of human MAGEA2.
Clone RB2194
Isotype Ig
Specificity This MAGEA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MAGEA2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MAGEA2
Background MAGEA2 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci.
Molecular Weight 35055 DA
Gene ID 4101
UniProt NP_005352
Research Area Cancer, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Melanoma Antigen Family A, 2 (MAGEA2) (N-Term), (AA 81-108) antibody The anti-MAGEA2 N-term Antibody (ABIN390106) is used in Western blot to detect MAGEA2 in HL60 lysate.
anti-Melanoma Antigen Family A, 2 (MAGEA2) (N-Term), (AA 81-108) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications van der Bruggen, Traversari, Chomez et al.: "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma." in: Science (New York, N.Y.), Vol. 254, Issue 5038, pp. 1643-7, 1992 (PubMed).

De Plaen, Arden, Traversari et al.: "Structure, chromosomal localization, and expression of 12 genes of the MAGE family." in: Immunogenetics, Vol. 40, Issue 5, pp. 360-9, 1994 (PubMed).

De Smet, Lurquin, van der Bruggen et al.: "Sequence and expression pattern of the human MAGE2 gene." in: Immunogenetics, Vol. 39, Issue 2, pp. 121-9, 1994 (PubMed).

Rogner, Wilke, Steck et al.: "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28." in: Genomics, Vol. 29, Issue 3, pp. 725-31, 1996 (PubMed).

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