Melanoma Antigen Family H, 1 (MAGEH1) (C-Term), (AA 186-218) antibody

Details for Product No. ABIN390121
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Antigen
Synonyms MAGEH1, APR-1, APR1, MAGEH, 2010107K23Rik
Epitope
C-Term, AA 186-218
(9), (5), (3), (1), (1)
Reactivity
Human
(24), (2), (2)
Host
Rabbit
(21), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(17), (16), (9), (6), (4), (4)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN390121
291.50 $
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Immunogen This MAGEH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-218 AA from the C-terminal region of human MAGEH1.
Clone RB2129
Isotype Ig
Specificity This MAGEH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190~219 amino acids from the C-terminal region of human MAGEH1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MAGEH1
Background Melanoma-associated antigen (MAGE) are completely silent in normal tissues, with the exception of male germ cells, and, for some of them, placenta. These antigens ought to be strictly tumor specific, expressed in tumor cells of various histological types. Because of their specific expression on tumor cells, these antigens are of particular interest for antitumor immunotherapy. Genes of the MAGE family direct the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes. Though the function of MAGEH1 is not fully elucidated, it may play a role in embryonal development and tumor transformation or aspects of tumor progression.
Synonyms: Melanoma-associated antigen H1, MAGE-H1 antigen, Restin, MAGE-H1 antigen, APR-1, APR1
Molecular Weight 24441 DA
Gene ID 28986
UniProt Q9H213
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Melanoma Antigen Family H, 1 (MAGEH1) (C-Term), (AA 186-218) antibody The anti-MAGEH1 Pab (ABIN390121) is used in Western blot to detect MAGEH1 in Jurkat cell lysate.
anti-Melanoma Antigen Family H, 1 (MAGEH1) (C-Term), (AA 186-218) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Melanoma Antigen Family H, 1 (MAGEH1) (C-Term), (AA 186-218) antibody (3) Western blot analysis of MAGEH1 (arrow) using rabbit polyclonal MAGEH1 Antibody (D201) (ABIN390121). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MAGEH1 gene.
Background publications Zhu, Yan, Zhao et al.: "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes." in: BioTechniques, Vol. 29, Issue 2, pp. 310-3, 2000 (PubMed).

Chomez, De Backer, Bertrand et al.: "An overview of the MAGE gene family with the identification of all human members of the family." in: Cancer research, Vol. 61, Issue 14, pp. 5544-51, 2001 (PubMed).

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