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DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 20-49), (N-Term) antibody

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Synonyms redd1, Dig2, REDD-1, REDD1, 5830413E08Rik, AA415483, Rtp801, dig2, rtp801, sb:cb821, zgc:64114
AA 20-49, N-Term
(32), (21), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(87), (34), (32)
(83), (5)
Clonality (Clone)
Polyclonal ()
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(70), (48), (42), (15), (11), (9), (5), (5), (4), (3)
Pubmed 1 reference available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This DDIT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 AA from the N-terminal region of human DDIT4.
Clone RB12592
Isotype Ig
Specificity This DDIT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27~57 amino acids from the C-terminal region of human DDIT4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DDIT4 (DDIT4 Antibody Abstract)
Background REDD1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS), TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD1. Thus, REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.
Synonyms: Protein regulated in development and DNA damage response 1, REDD-1, HIF-1 responsive protein RTP801
Molecular Weight 25240 DA
Gene ID 54541
UniProt Q9NX09
Research Area Transcription Factors, Signaling
Pathways Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 20-49), (N-Term) antibody (ABIN390207) Western blot analysis of DDIT4 Antibody (N-term) (ABIN390207) in Jurkat cell line lys...
Immunohistochemistry (IHC) image for anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 20-49), (N-Term) antibody (ABIN390207) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with DDIT4 a...
Background publications Ellisen, Ramsayer, Johannessen et al.: "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species." in: Molecular cell, Vol. 10, Issue 5, pp. 995-1005, 2002 (PubMed).

Catalog No. ABIN390207
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