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Details for Product No. ABIN390379

G Protein-Coupled Receptor 37 (GPR37) (N-Term), (AA 97-126) antibody

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Antigen
Synonyms AI848630, Pael-R, Ednrbl
Epitope
»Alternatives N-Term, AA 97-126
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN390379
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This Pael-R (GPR37) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 AA from the N-terminal region of human Pael-R (GPR37).
Clone RB7395
Isotype Ig
Specificity This Pael-R (GPR37) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104~134 amino acids from the N-terminal region of human Pael-R (GPR37).
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Pael-R (GPR37)
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons, coexpression of Parkin degrades Pael-R and suppresses its toxicity.
Synonyms: Endothelin B receptor-like protein-1, ETBR-LP-1, Parkin-associated endothelin receptor-like receptor, endothelin receptor type B-like, PAELR, G protein-coupled receptor 37, GPR37
Molecular Weight 67114 DA
Gene ID 2861
UniProt NP_005293
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Marazziti, Golini, Gallo et al.: "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library." in: Genomics, Vol. 45, Issue 1, pp. 68-77, 1997 (PubMed).

Imai, Soda, Inoue et al.: "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin." in: Cell, Vol. 105, Issue 7, pp. 891-902, 2001 (PubMed).

Yang, Nishimura, Imai et al.: "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila." in: Neuron, Vol. 37, Issue 6, pp. 911-24, 2003 (PubMed).

Alternatives for antigen "G Protein-Coupled Receptor 37 (GPR37)", type "Antibodies"
Hosts (3)
Reactivities (3), (1)
Applications (3), (3)
Epitopes (2), (2), (1), (1)
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