Exportin 1, CRM1 Homolog (Yeast) (XPO1) (C-Term), (AA 817-846) antibody

Details for Product No. ABIN390636
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Antigen
Epitope
C-Term, AA 817-846
(4), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(32), (22), (21), (18), (16), (12), (12), (3), (1), (1)
Host
Rabbit
(33)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(23), (10), (8), (5), (4), (2), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN390636
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Immunogen This XPO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 817-846 AA from the C-terminal region of human XPO1.
Clone RB19972
Isotype Ig
Specificity This XPO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 824~854 amino acids from the C-terminal region of human XPO1.
Predicted Reactivity Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name XPO1
Background XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Synonyms: Exportin-1, Exp1, Chromosome region maintenance 1 protein homolog, CRM1, XPO1
Molecular Weight 123386 DA
Gene ID 7514
UniProt O14980
Research Area Cancer, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Exportin 1, CRM1 Homolog (Yeast) (XPO1) (C-Term), (AA 817-846) antibody Western blot analysis of XPO1 antibody (C-term) (ABIN390636) in mouse bladder tissue lysates (35 µg/lane). XPO1 (arrow) was detected using the purified polyclonal antibody.
anti-Exportin 1, CRM1 Homolog (Yeast) (XPO1) (C-Term), (AA 817-846) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with XPO1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Exportin 1, CRM1 Homolog (Yeast) (XPO1) (C-Term), (AA 817-846) antibody (3) Flow cytometric analysis of widr cells using XPO1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Dong, Biswas, Chook: "Structural basis for assembly and disassembly of the CRM1 nuclear export complex." in: Nature structural & molecular biology, Vol. 16, Issue 5, pp. 558-60, 2009 (PubMed).

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