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ADRBK2 antibody (Adrenergic, Beta, Receptor Kinase 2) (AA 633-660)

Details for Product anti-ADRBK2 Antibody No. ABIN390986, Supplier: Log in to see
Antigen
  • bark2
  • grk3
  • 4833444A01Rik
  • AI851927
  • AW551196
  • Adrbk-2
  • Bark-2
  • GRK3
  • BARK2
  • Grk3
  • si:dz221d18.1
Epitope
AA 633-660, C-Term
32
20
16
15
4
1
1
1
1
1
1
1
1
1
Reactivity
Human, Monkey, Mouse (Murine)
98
39
35
3
1
1
Host
Rabbit
99
2
Clonality (Clone)
Polyclonal ()
Conjugate
This ADRBK2 antibody is un-conjugated
8
7
7
6
6
6
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
80
60
40
11
9
2
1
1
Supplier
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Immunogen This AD_K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 AA from the C-terminal region of human AD_K2.
Clone RB00896
Isotype Ig
Specificity This GRK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639~669 amino acids from the C-term region of human GRK3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GRK3 (ADRBK2 Antibody Abstract)
Background The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Synonyms: G-protein coupled receptor kinase 3, Beta-adrenergic receptor kinase 2, Beta-ARK-2
Molecular Weight 79677 DA
Gene ID 157
UniProt P35626
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ADRBK2 antibody (Adrenergic, Beta, Receptor Kinase 2) (AA 633-660) (ABIN390986) The anti-GRK3 Pab (ABIN390986) is used in Western blot to detect GRK3 in SK-OV-3 cell...
Product cited in: Rao, Rapoport, Kim: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, 2009 (PubMed).

Background publications Parruti, Ambrosini, Sallese et al.: "Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2." in: Biochemical and biophysical research communications, Vol. 190, Issue 2, pp. 475-81, 1993 (PubMed).

Calabrese, Sallese, Stornaiuolo et al.: "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes." in: Genomics, Vol. 23, Issue 1, pp. 286-8, 1995 (PubMed).

Benovic, Onorato, Arriza et al.: "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family." in: The Journal of biological chemistry, Vol. 266, Issue 23, pp. 14939-46, 1991 (PubMed).