Adrenergic, Beta, Receptor Kinase 2 (ADRBK2) (C-Term), (AA 633-660) antibody

Details for Product No. ABIN390986
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Antigen
Synonyms GRK3, BARK2, Grk3, si:dz221d18.1, 4833444A01Rik, AI851927, AW551196, Adrbk-2, Bark-2, bark2, grk3
Epitope
C-Term, AA 633-660
(3), (3), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Monkey
(42), (31), (30), (13), (13), (12), (12), (1)
Host
Rabbit
(42), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(33), (18), (10), (7), (5), (2), (1)
Pubmed 4 references available
Catalog no. ABIN390986
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This AD_K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 AA from the C-terminal region of human AD_K2.
Clone RB00896
Isotype Ig
Specificity This GRK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639~669 amino acids from the C-term region of human GRK3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GRK3
Background The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Synonyms: G-protein coupled receptor kinase 3, Beta-adrenergic receptor kinase 2, Beta-ARK-2
Molecular Weight 79677 DA
Gene ID 157
UniProt P35626
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Adrenergic, Beta, Receptor Kinase 2 (ADRBK2) (C-Term), (AA 633-660) antibody The anti-GRK3 Pab (ABIN390986) is used in Western blot to detect GRK3 in SK-OV-3 cell lysate (Lane 1) and mouse heart tissue lysate (Lane 2).
Background publications Benovic, Onorato, Arriza et al.: "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family." in: The Journal of biological chemistry, Vol. 266, Issue 23, pp. 14939-46, 1991 (PubMed).

Calabrese, Sallese, Stornaiuolo et al.: "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes." in: Genomics, Vol. 23, Issue 1, pp. 286-8, 1995 (PubMed).

Parruti, Ambrosini, Sallese et al.: "Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2." in: Biochemical and biophysical research communications, Vol. 190, Issue 2, pp. 475-81, 1993 (PubMed).

General Rao, Rapoport, Kim: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, 2009 (PubMed).

Hosts (42), (1)
Reactivities (42), (31), (30), (13), (13), (12), (12), (1)
Applications (33), (18), (10), (7), (5), (2), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (2), (2), (1), (1), (1)
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