MSK2 (C-Term), (AA 322-354) antibody

Details for Product No. ABIN390994
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Synonyms 1110069D02Rik, 90kDa, AI848992, Msk2, mMSK2, MSK2, RSK-B
C-Term, AA 322-354
(8), (6), (4), (3), (1), (1), (1), (1)
Human, Mouse (Murine)
(34), (13)
(31), (3)
Clonality (Clone)
Polyclonal ()
Western Blotting (WB)
(28), (17), (6), (4), (3), (2), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN390994
Quantity 400 µL
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Immunogen This RSKB (MSK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-354 AA from the C-terminal region of human RSKB (MSK2).
Clone RB1020
Isotype Ig
Specificity This RSKB (MSK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315~344 amino acids from the C-terminal region of human MSK2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name RSKB (MSK2)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).
Synonyms: Mitogen-and stress-activated protein kinase-2
Molecular Weight 85605 Da
Gene ID 8986
UniProt O75585
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-MSK2 (C-Term), (AA 322-354) antibody The anti-MSK2 Pab (ABIN390994) is used in Western blot to detect MSK2 in placenta tissue lysate. Indirect immunofluorescence analysis showed that MSK2 is predominantly localized in the nucleus of parental (10T1/2) and oncogene-transformed (Ciras-3) mouse fibroblasts. Cells were co-stained with DAPI to visualize nucleus compartment. Data is kindly provided by B. Drobic and Dr. J. Davie from University of Manitoba (Winnipeg, Canada).
Background publications Deak, Clifton, Lucocq et al.: "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB." in: The EMBO journal, Vol. 17, Issue 15, pp. 4426-41, 1998 (PubMed).

Pierrat, Correia, Mary et al.: "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)." in: The Journal of biological chemistry, Vol. 273, Issue 45, pp. 29661-71, 1998 (PubMed).

Zhu, Gerhard: "A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1." in: Human genetics, Vol. 103, Issue 6, pp. 674-80, 1999 (PubMed).

Hosts (31), (3)
Reactivities (34), (13)
Applications (28), (17), (6), (4), (3), (2), (1), (1), (1)
Epitopes (8), (6), (4), (3), (1), (1), (1), (1)
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