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Details for Product No. ABIN391125

Deoxycytidine Kinase (DCK) (C-Term), (AA 171-200) antibody

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Antigen
Synonyms wu:fc15f06, zgc:101771, dck, DCK, Dck, dck2, wu:fe11h12, wu:fj05e11, zgc:109951
Epitope
»Alternatives C-Term, AA 171-200
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting (WB), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN391125
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This DCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 AA from the C-terminal region of human DCK.
Clone RB05276
Isotype Ig
Specificity This DCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178~207 amino acids from the C-terminal region of human DCK.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DCK
Background Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.
Synonyms: Deoxycytidine kinase, dCK
Molecular Weight 30518 DA
Gene ID 1633
UniProt P27707
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes Recommend dilutions: IHC : 1:10-50,IF : 1:10-50,WB : 1:1000,IP : 1:500-1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Chottiner, Shewach, Datta et al.: "Cloning and expression of human deoxycytidine kinase cDNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 4, pp. 1531-5, 1991 (PubMed).

Hartford, Duan, Delaney et al.: "Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity." in: Blood, Vol. 113, Issue 10, pp. 2145-53, 2009 (PubMed).

Alternatives for antigen "Deoxycytidine Kinase (DCK)", type "Antibodies"
Hosts (40), (24)
Reactivities (62), (22), (19), (12), (2), (2), (1), (1), (1)
Applications (47), (23), (11), (10), (9), (8), (6), (6), (5), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (4), (3), (2), (2), (1)
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