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Details for Product No. ABIN391217

STE20-Related Kinase Adaptor alpha (STRADA) (N-Term), (AA 12-41) antibody

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Antigen
Synonyms AI480680, 2610019A05Rik, 6030402H20Rik, E130112C09Rik, LYK5, STRAD, NY-BR-96, PMSE, Stlk, Lyk5, fj99g05, zgc:56109, wu:fj99g05, lyk5
Epitope
»Alternatives N-Term, AA 12-41
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN391217
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This LYK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-41 AA from the N-terminal region of human LYK5.
Clone RB8539
Isotype Ig
Specificity This LYK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19~49 amino acids from the N-terminal region of human LYK5.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LYK5
Background LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
Synonyms: STE20-related adaptor protein, STRAD alpha, Serologically defined breast cancer antigen NY-BR-96, STRAD
Molecular Weight 48369 DA
Gene ID 92335
UniProt Q7RTN6
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Baas, Boudeau, Sapkota et al.: "Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD." in: The EMBO journal, Vol. 22, Issue 12, pp. 3062-72, 2003 (PubMed).

Alternatives for antigen "STE20-Related Kinase Adaptor alpha (STRADA)", type "Antibodies"
Hosts (40), (3)
Reactivities (41), (19), (13), (13), (13), (12), (2)
Applications (34), (18), (10), (5), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (7), (2), (2), (2), (1), (1), (1), (1), (1)
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