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ADAMTS13 antibody (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13) (AA 829-858)

Details for Product anti-ADAMTS13 Antibody No. ABIN391641, Supplier: Login to see
Antigen
  • ADAMTS13
  • ADAMTS12
  • Gm710
  • vWF-CP
  • ADAM-TS13
  • ADAMTS-13
  • C9orf8
  • VWFCP
Epitope
AA 829-858, Center
14
8
7
6
4
4
3
2
2
2
2
2
2
2
1
1
Reactivity
Human
68
15
14
1
Host
Rabbit
39
14
11
4
Clonality (Clone)
Polyclonal ()
Conjugate
This ADAMTS13 antibody is un-conjugated
5
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
43
28
13
11
10
5
4
3
2
2
2
1
1
Supplier
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Immunogen This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 AA from the Central region of human ADAMTS13.
Clone RB18029
Isotype Ig
Specificity This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836~866 amino acids from the center region of human ADAMTS13.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ADAMTS13 (ADAMTS13 Antibody Abstract)
Background ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
Synonyms: von Willebrand factor-cleaving protease, vWF-cleaving protease, vWF-CP, A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAMTS-13, ADAM-TS 13, ADAM-TS13, ADAMTS13, C9orf8
Molecular Weight 153604 DA
Gene ID 11093
UniProt Q76LX8
Research Area Metabolism, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ADAMTS13 antibody (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13) (AA 829-858) (ABIN391641) Western blot analysis of anti-ADAMTS13 Antibody (Center)(ABIN391641) in CEM cell line...
Immunohistochemistry (IHC) image for anti-ADAMTS13 antibody (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13) (AA 829-858) (ABIN391641) Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody (Ce...
Background publications Plaimauer, Fuhrmann, Mohr et al.: "Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation." in: Blood, Vol. 107, Issue 1, pp. 118-25, 2005 (PubMed).

Levy, Nichols, Lian et al.: "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura." in: Nature, Vol. 413, Issue 6855, pp. 488-94, 2001 (PubMed).

Zheng, Chung, Takayama et al.: "Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 41059-63, 2001 (PubMed).