ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) (AA 829-858), (Center) antibody

Details for Product No. ABIN391641
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Antigen
Synonyms ADAMTS13, ADAMTS12, Gm710, vWF-CP, ADAM-TS13, ADAMTS-13, C9orf8, VWFCP
Epitope
AA 829-858, Center
(7), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(43), (12), (12), (12), (12), (12)
Host
Rabbit
(24), (9), (8), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(25), (17), (11), (11), (10), (5), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN391641
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Immunogen This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 AA from the Central region of human ADAMTS13.
Clone RB18029
Isotype Ig
Specificity This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836~866 amino acids from the center region of human ADAMTS13.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ADAMTS13
Background ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
Synonyms: von Willebrand factor-cleaving protease, vWF-cleaving protease, vWF-CP, A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAMTS-13, ADAM-TS 13, ADAM-TS13, ADAMTS13, C9orf8
Molecular Weight 153604 DA
Gene ID 11093
UniProt Q76LX8
Research Area Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) (AA 829-858), (Center) antibody Western blot analysis of anti-ADAMTS13 Antibody (Center)(ABIN391641) in CEM cell line lysates (35 µg/lane). ADAMTS13 (arrow) was detected using the purified polyclonal antibody.
anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) (AA 829-858), (Center) antibody (2) Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Zheng, Chung, Takayama et al.: "Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 41059-63, 2001 (PubMed).

Levy, Nichols, Lian et al.: "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura." in: Nature, Vol. 413, Issue 6855, pp. 488-94, 2001 (PubMed).

Plaimauer, Fuhrmann, Mohr et al.: "Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation." in: Blood, Vol. 107, Issue 1, pp. 118-25, 2005 (PubMed).

Validation Images
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