Immunoglobulin Heavy Constant alpha 1 (IGHA1) (C-Term), (AA 257-286) antibody

Details for Product No. ABIN391663
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Antigen
Synonyms IgA1
Epitope
C-Term, AA 257-286
(4), (1), (1)
Reactivity
Human
(9)
Host
Rabbit
(6), (3)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(7), (6), (3), (2), (2)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN391663
291.50 $
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Immunogen This IGHA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 AA from the C-terminal region of human IGHA1.
Clone RB18272
Isotype Ig
Specificity This IGHA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264~294 amino acids from the C-terminal region of human IGHA1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IGHA1
Background Ig alpha is the major immunoglobulin class in body secretions. The protein may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
Synonyms: Ig alpha-1 chain C region , IGHA1
Molecular Weight 37655 DA
Gene ID 3493
UniProt P01876
Research Area Cancer, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Immunoglobulin Heavy Constant alpha 1 (IGHA1) (C-Term), (AA 257-286) antibody Western blot analysis of IgA antibody (C-term) (ABIN391663) in CEM cell line lysates (35 µg/lane). IgA (arrow) was detected using the purified polyclonal antibody .
anti-Immunoglobulin Heavy Constant alpha 1 (IGHA1) (C-Term), (AA 257-286) antibody (2) Formalin-fixed and paraffin-embedded human Lymph reacted with IgA Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Immunoglobulin Heavy Constant alpha 1 (IGHA1) (C-Term), (AA 257-286) antibody (3) Flow cytometric analysis of CEM cells using IgA Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Putnam, Liu, Low: "Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain." in: The Journal of biological chemistry, Vol. 254, Issue 8, pp. 2865-74, 1979 (PubMed).

Flanagan, Lefranc, Rabbitts: "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences." in: Cell, Vol. 36, Issue 3, pp. 681-8, 1984 (PubMed).

Hatzivassiliou, Miller, Takizawa et al.: "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy." in: Immunity, Vol. 14, Issue 3, pp. 277-89, 2001 (PubMed).

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