Growth Differentiation Factor 6 (GDF6) (C-Term), (AA 326-353) antibody

Details for Product No. ABIN391699
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Antigen
Synonyms gdf6, rdr, sb:cb278, BMP13, CDMP2, KFM, KFS, KFS1, KFSL, LCA17, MCOP4, MCOPCB6, SCDO4, SGM1, GDF16, gdf16, CDMP-2, GDF6/7
Epitope
C-Term, AA 326-353
(11), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(34), (25), (19), (12), (12)
Host
Rabbit
(37)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(28), (13), (10), (9), (7), (5), (2), (2)
Pubmed 1 reference available
Quantity 400 μL
Options
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Catalog No. ABIN391699
291.50 $
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Immunogen This GDF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-353 AA from the C-terminal region of human GDF6.
Clone RB15615
Isotype Ig
Specificity This GDF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333~362 amino acids from the C-terminal region of human GDF6.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GDF6
Background GDF6 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this protein result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.
Synonyms: Growth/differentiation factor 6, GDF-6, Growth/differentiation factor 16, GDF16, GDF6
Molecular Weight 50662 DA
Gene ID 392255
UniProt Q6KF10
Research Area Cell Signaling, Stem Cells, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Growth Differentiation Factor 6 (GDF6) (C-Term), (AA 326-353) antibody Western blot analysis of GDF6 antibody (C-term) (ABIN391699) in mouse kidney tissue lysates (35 µg/lane). GDF6 (arrow) was detected using the purified polyclonal antibody.
anti-Growth Differentiation Factor 6 (GDF6) (C-Term), (AA 326-353) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with GDF6 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Growth Differentiation Factor 6 (GDF6) (C-Term), (AA 326-353) antibody (3) Flow cytometric analysis of 293 cells using GDF6 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Tassabehji, Fang, Hilton et al.: "Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome." in: Human mutation, Vol. 29, Issue 8, pp. 1017-27, 2008 (PubMed).

Validation Images
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