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Cyclin-Dependent Kinase 18 (CDK18) (N-Term), (AA 25-55) antibody

Details for Product No. ABIN391790
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Antigen
Epitope
N-Term, AA 25-55
(14), (10), (8), (7), (2), (1)
Reactivity
Human
(20), (18), (3), (1), (1)
Host
Rabbit
(32), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(33), (23), (6), (3), (2), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN391790
291.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This PCTAIRE3 (PCTK3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 AA from the N-terminal region of human PCTAIRE3 (PCTK3).
Clone RB3364
Isotype Ig
Specificity This PCTK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of human PCTK3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PCTAIRE3 (PCTK3)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway. The CMGC group consists of 60 kinases including the cyclin-dependent kinase (CDK) and close relatives family, the MAP kinase (ERK) family, the glycogen synthase kinase 3 (GSK3) family, and the Cdc2-like kinase (CLK) family.
Synonyms: Serine/threonine protein kinase PCTAIRE-3
Molecular Weight 54210 DA
Gene ID 5129
UniProt NP_002587
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Transcription Factors, Signaling, Metabolism
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin-Dependent Kinase 18 (CDK18) (N-Term), (AA 25-55) antibody Western blot analysis of PCTK3 (arrow) using rabbit polyclonal PCTK3 Antibody (N40) (ABIN391790). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PCTK3 gene.
anti-Cyclin-Dependent Kinase 18 (CDK18) (N-Term), (AA 25-55) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Cyclin-Dependent Kinase 18 (CDK18) (N-Term), (AA 25-55) antibody (3) The anti-PCTK3 Pab (ABIN391790) is used in Western blot to detect PCTK3 in HL-60 cell lysate.
Background publications Meyerson, Enders, Wu et al.: "A family of human cdc2-related protein kinases." in: The EMBO journal, Vol. 11, Issue 8, pp. 2909-17, 1992 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN391790
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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