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Megakaryocyte-Associated tyrosine Kinase (MATK) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN392103
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Antigen
Synonyms CHK, CTK, HHYLTK, HYL, HYLTK, Lsk, Batk, Ntk, si:ch211-63j24.2
Epitope
N-Term, AA 1-30
(9), (9), (7), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(46), (29), (19), (12), (12), (12), (1)
Host
Rabbit
(44), (12)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(47), (32), (19), (10), (7), (7), (1), (1)
Pubmed 4 references available
Quantity 400 µL
Options
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Catalog No. ABIN392103
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This MATK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human MATK.
Clone RB03166
Isotype Ig
Specificity This MATK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human MATK.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MATK
Background MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
Synonyms: Megakaryocyte-associated tyrosine-protein kinase, Tyrosine-protein kinase CTK, Protein kinase HYL, Hematopoietic consensus tyrosine-lacking kinase
Molecular Weight 56469 DA
Gene ID 4145
UniProt P42679
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Megakaryocyte-Associated tyrosine Kinase (MATK) (N-Term), (AA 1-30) antibody MATK Antibody (M1) (ABIN392103) western blot analysis in HL-60 cell line lysates (35 µg/lane).This demonstrates the MATK antibody detected the MATK protein (arrow).
Background publications Avraham, Jiang, Ota et al.: "Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product." in: The Journal of biological chemistry, Vol. 270, Issue 4, pp. 1833-42, 1995 (PubMed).

Jhun, Rivnay, Price et al.: "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit." in: The Journal of biological chemistry, Vol. 270, Issue 16, pp. 9661-6, 1995 (PubMed).

Kim, Zagozdzon, Meisler et al.: "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer." in: The Journal of biological chemistry, Vol. 277, Issue 39, pp. 36465-70, 2002 (PubMed).

Zagozdzon, Bougeret, Fu et al.: "Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells." in: International journal of oncology, Vol. 21, Issue 6, pp. 1347-52, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN392103
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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