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Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) (AA 580-609), (Ser601) antibody

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Synonyms b-raf, sm-e, sme, 9930012E13Rik, AA120551, AA387315, AA473386, B-raf, Braf-2, Braf2, C230098H17, C87398, D6Ertd631e, AL022645, C76690, SME, HYPT11, Sm-E, SmE, snRNP-E, zgc:56682, Snrpe
AA 580-609, Ser601
(14), (13), (13), (11), (8), (7), (6), (6), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(124), (98), (78), (6), (2), (2), (1), (1), (1)
(116), (5), (4)
Clonality (Clone)
Polyclonal ()
(8), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(77), (48), (39), (32), (19), (17), (9), (5), (5), (2), (1)
Pubmed 3 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This B-RAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 580-609 AA from human B-RAF.
Clone RB10945
Isotype Ig
Specificity This B-RAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S601 of human BRAF.
Predicted Reactivity Chicken,Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name B-RAF (SNRPE Antibody Abstract)
Background BRAF, a member of the RAF subfamily of Ser/Thr protein kinases, is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neurons. This cytoplasmic protein is expressed in brain and testis. Defects in BRAF are involved in a wide range of cancers including lung cancer and non-Hodgkin lymphoma (NHL). This protein contains 1 zinc-dependent phorbol-ester and DAG binding domain.
Synonyms: B-Raf proto-oncogene serine/threonine-protein kinase, p94, v-Raf murine sarcoma viral oncogene homolog B1
Molecular Weight 84490 DA
Gene ID 673
UniProt P15056
Research Area Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) (AA 580-609), (Ser601) antibody (ABIN392253) Western blot analysis of BRAF-pS601 (ABIN392253) in MCF7 cell line lysates (35 µg/lan...
Immunohistochemistry (IHC) image for anti-Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) (AA 580-609), (Ser601) antibody (ABIN392253) Formalin-fixed and paraffin-embedded human brain tissue reacted with BRAF Antibody (S...
Background publications Hingorani, Jacobetz, Robertson et al.: "Suppression of BRAF(V599E) in human melanoma abrogates transformation." in: Cancer research, Vol. 63, Issue 17, pp. 5198-202, 2003 (PubMed).

Naoki, Chen, Richards et al.: "Missense mutations of the BRAF gene in human lung adenocarcinoma." in: Cancer research, Vol. 62, Issue 23, pp. 7001-3, 2002 (PubMed).

Davies, Bignell, Cox et al.: "Mutations of the BRAF gene in human cancer. ..." in: Nature, Vol. 417, Issue 6892, pp. 949-54, 2002 (PubMed).

Catalog No. ABIN392253
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