seryl-tRNA Synthetase 2, Mitochondrial (SARS2) (N-Term), (AA 160-188) antibody

Details for Product No. ABIN392300
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Antigen
Epitope
N-Term, AA 160-188
(3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(15), (3), (3)
Host
Rabbit
(14), (1)
Clonality (Clone)
Polyclonal ()
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(14), (6), (4), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN392300
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Immunogen This SARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 AA from the N-terminal region of human SARS2.
Clone RB14927
Isotype Ig
Specificity This SARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167~196 amino acids from the N-terminal region of human SARS2.
Predicted Reactivity Cow (Bovine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SARS2
Background SARS2 catalyzes the attachment of serine to tRNA(Ser). It is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Synonyms: Seryl-tRNA synthetase, mitochondrial [Precursor], EC 6.1.1.11, Seryl-tRNA(Ser/Sec) synthetase, Serine--tRNA ligase, SerRSmt, SARS2, SARSM
Molecular Weight 58283 DA
Gene ID 54938
UniProt Q9NP81
Research Area Metabolism, Cell Structure
Application Notes IHC = 1:10-50, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-seryl-tRNA Synthetase 2, Mitochondrial (SARS2) (N-Term), (AA 160-188) antibody Western blot analysis of anti-SARS2 Pab (ABIN392300) in 293 cell line lysates (35 µg/lane). SARS2(arrow) was detected using the purified polyclonal antibody.
anti-seryl-tRNA Synthetase 2, Mitochondrial (SARS2) (N-Term), (AA 160-188) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with SARS2 antibody (N-term) (ABIN392300), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Yokogawa, Shimada, Takeuchi et al.: "Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19913-20, 2000 (PubMed).

Gibbons, Yan, Li et al.: "Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase." in: Biochemical and biophysical research communications, Vol. 317, Issue 3, pp. 774-8, 2004 (PubMed).

Müller, Deschauer, Neudecker et al.: "Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene." in: Acta neuropathologica, Vol. 110, Issue 4, pp. 426-30, 2005 (PubMed).

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