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Details for Product No. ABIN392338

AAK1 (C-Term), (AA 790-819) antibody

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Synonyms 5530400K14Rik, 9630042K20, AU067724, AU067726, BC028270, C79663, D6Ertd245e, R75501, mKIAA1048, RGD1563580
»Alternatives C-Term, AA 790-819
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN392338
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This AAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 790-819 AA from the C-terminal region of human AAK1.
Clone RB16779
Isotype Ig
Specificity This AAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 797~827 amino acids from the C-terminal region of human AAK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 is a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.
Synonyms: AP2-associated protein kinase 1, Adaptor-associated kinase 1, AAK1, KIAA1048
Molecular Weight 93578 DA
Gene ID 22848
UniProt Q2M2I8
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Takahashi, Furuchi, Naganuma: "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells." in: Cancer research, Vol. 66, Issue 24, pp. 11932-7, 2006 (PubMed).

Henderson, Conner: "A novel AAK1 splice variant functions at multiple steps of the endocytic pathway." in: Molecular biology of the cell, Vol. 18, Issue 7, pp. 2698-706, 2007 (PubMed).

Alternatives for antigen "AAK1", type "Antibodies"
Hosts (60), (3), (3)
Reactivities (62), (40), (35), (1)
Applications (56), (26), (10), (10), (9), (5), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (12), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)