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AAK1 (C-Term), (AA 790-819) antibody

Details for Product No. ABIN392338
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Antigen
Epitope
C-Term, AA 790-819
(15), (10), (10), (7), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(69), (52), (43), (1)
Host
Rabbit
(71), (3), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(67), (37), (10), (10), (10), (10), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN392338
291.50 $
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This AAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 790-819 AA from the C-terminal region of human AAK1.
Clone RB16779
Isotype Ig
Specificity This AAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 797~827 amino acids from the C-terminal region of human AAK1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 is a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.
Synonyms: AP2-associated protein kinase 1, Adaptor-associated kinase 1, AAK1, KIAA1048
Molecular Weight 93578 DA
Gene ID 22848
UniProt Q2M2I8
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-AAK1 (C-Term), (AA 790-819) antibody Western blot analysis of anti-AAK1 Antibody (C-term) (ABIN392338) in HepG2 cell line lysates (35 µg/lane). AAK1 (arrow) was detected using the purified polyclonal antibody.
Background publications Takahashi, Furuchi, Naganuma: "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells." in: Cancer research, Vol. 66, Issue 24, pp. 11932-7, 2006 (PubMed).

Henderson, Conner: "A novel AAK1 splice variant functions at multiple steps of the endocytic pathway." in: Molecular biology of the cell, Vol. 18, Issue 7, pp. 2698-706, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN392338
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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