PI3KR1 (PI3KR1) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN392570
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Antigen
Epitope
N-Term, AA 1-30
(1), (1)
Reactivity
Human
(1)
Host
Rabbit
(1)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(1), (1)
Pubmed 4 references available
Quantity 400 µL
Options
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Catalog No. ABIN392570
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Immunogen This PI3KR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human PI3KR1.
Clone RB11634
Isotype Ig
Specificity This PI3KR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3~33 amino acids from the N-terminal region starting with leucine at position 11 of human PI3KR1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PI3KR1
Background Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance.
Synonyms: Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase p85-subunit alpha, PtdIns-3-kinase p85-alpha, PI3K, PIK3R1, GRB1,
Molecular Weight 83598 DA
Gene ID 5295
UniProt P27986
Research Area Autophagy, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-PI3KR1 (PI3KR1) (N-Term), (AA 1-30) antibody Western blot analysis of anti-PIK3R1 Antibody (N-term L11) Pab (ABIN392570) in CEM cell line lysates (35 µg/lane). PIK3R1(arrow) was detected using the purified polyclonal antibody (1:63 dilution).
anti-PI3KR1 (PI3KR1) (N-Term), (AA 1-30) antibody (2) Western blot analysis of anti-PIK3R1 Antibody (N-term L11) Pab (ABIN392570) in Hela cell line lysates (35 µg/lane). PIK3R1(arrow) was detected using the purified polyclonal antibody (1:63 dilution).
anti-PI3KR1 (PI3KR1) (N-Term), (AA 1-30) antibody (3) Western blot analysis of anti-PI3KR1 Antibody (N-term L11) Pab (ABIN392570) in 293 cell line lysates transiently transfected with the PIK3R1 gene (3 µg/lane). PI3KR1(arrow) was detected using the purified polyclonal antibody (1:60 dilution).
Background publications Lee, Srinivas, Xia et al.: "Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23630-8, 2003 (PubMed).

Sun, Yang, Feldman et al.: "Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 42992-3000, 2003 (PubMed).

Kobayashi, Suzuki, Kanayama et al.: "Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells." in: The Journal of biological chemistry, Vol. 279, Issue 8, pp. 6371-9, 2004 (PubMed).

Liu, Radisky, Wang et al.: "Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells." in: The Journal of cell biology, Vol. 164, Issue 4, pp. 603-12, 2004 (PubMed).

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