Interleukin 17A (IL17A) antibody

Details for Product No. ABIN401113
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Synonyms Il17, IL17A, CTLA8, IL-17, IL-17A, IL17, Ctla-8, Ctla8, CTLA-8, ChIL-17, IL-17F
Mouse (Murine), Rat (Rattus)
(199), (109), (31), (4), (1), (1), (1), (1), (1), (1)
(128), (99), (52), (14), (3), (3), (1)
(48), (14), (12), (12), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(159), (150), (96), (35), (25), (22), (20), (16), (14), (13), (9), (7), (7), (7), (6), (4), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN401113
390.50 $
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Immunogen Full-length recombinant Rat IL17-A protein . Genename: IL17A
Isotype IgG
Specificity This antibody will recognize both native and recombinant Rat IL17-A in cell supernatants and certain body fluids. Reactivity is also expected in Neutralizations, Radioimmunoassay and Immunohistochemistry. A control of similarly diluted Normal Rabbit IgG is recommended. By western blot from a reducing gel expect a band approximately 15.0 kDa in size corresponding to Rat IL17-A protein in the appropriate cell lysate or extract.
Purification Ig Fraction
Alternative Name Interleukin-17A (IL17A)
Background Rat IL17-A (also known as Interleukin-17, Cytotoxic T-lymphocyteassociated antigen 8 and CTLA-8) is a proinflammatory cytokine member of a six-species family of proteins (IL-17A-17F). Rat IL-17A protein is a homodimer consisting of two 134 amino acids peptides. IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most strikingly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. There is 58% identity between the amino acid sequence of Human and Rat IL-17A.
Alternate names: CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17
Gene ID 10116
UniProt Q61453
Research Area Cytokines, Receptors, Inflammation, Immunology, Virology, Cancer
Application Notes ELISA: 1/20000 - 1/100000. Western Blot: 1/500 - 1/2000. Neutralization: 1/400. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL of deionized water (or equivalent).
Concentration 1.0 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02M Potassium Phosphate, 0.15M Sodium Chloride, pH 7.2 without preservatives and stabilizers.The Endotoxin content is estimated to be less than 10 pg/ml by the LAL method.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Interleukin 17A (IL17A) antibody anti-Interleukin 17A (IL17A) antibody
anti-Interleukin 17A (IL17A) antibody (2) anti-Interleukin 17A (IL17A) antibody (Image 2)
Background publications Rouvier, Luciani, Mattéi et al.: "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 12, pp. 5445-56, 1993 (PubMed).

Yao, Timour, Painter et al.: "Complete nucleotide sequence of the mouse CTLA8 gene." in: Gene, Vol. 168, Issue 2, pp. 223-5, 1996 (PubMed).

Kennedy, Rossi, Zurawski et al.: "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 16, Issue 8, pp. 611-7, 1997 (PubMed).

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