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Parkinson Protein 7 (PARK7) (AA 177-189) antibody

Details for Product No. ABIN401278
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Antigen
Synonyms dj1, zgc:103725, DJ-1, Dj1, DJ1, CAP1, SP22
Epitope
AA 177-189
(27), (18), (8), (7), (6), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chimpanzee, Human, Monkey, Zebrafish (Danio rerio)
(156), (71), (56), (16), (15), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(129), (31), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(152), (91), (42), (36), (20), (20), (10), (10), (9), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN401278
390.50 $
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Immunogen Synthetic peptide corresponding aa 177-189 of Human PARK7 protein
Isotype IgG
Specificity Thisa ntibody is specific for PARK7.
Purification Immunoaffinity chromatography
Alternative Name DJ-1 / PARK7
Background The product of the PARK7 gene, known as PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product, functions as a positive regulator of androgen receptor-dependent transcription. PARK7 may also function as a redoxsensitive chaperone and as a sensor for oxidative stress and also has been reported to prevent aggregation of SNCA. PARK7 protects neurons against oxidative stress and cell death and plays a role in fertilization. While PARK7 has no proteolytic activity, it does have a weak transforming activity. PARK7 forms a homodimer and binds to DJBP and PIAS2. PARK7 is part of a ternary complex containing PARK7, DJBP and AR and shows both a nuclear and cytoplasmic localization. In some cells, PARK7 is associated with mitochondria, particularly after oxidative stress. This protein is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart tissue, and is expressed at lower levels in placenta and brain. PARK7 is detected in tau inclusions in brains from neurodegenerative disease patients, in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, response to treatment with levodopa, the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins) in surviving neurons.
Alternate names: Oncogene DJ1, Parkinson disease protein 7
Gene ID 11315
NCBI Accession NP_001116849.1
UniProt Q99497
Application Notes ELISA: 1: 10,000 - 1: 50,000. Immunohistochemistry on paraffin sections: 2 µg/ml - 5 µg/ml. Western blot: 1: 500 - 1: 2,000 (Expect a band approximately 28 kDa in size correspondingto PARK7 in the appropriate cell lysate or extract). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.3 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Supplier Images
anti-Parkinson Protein 7 (PARK7) (AA 177-189) antibody anti-Parkinson Protein 7 (PARK7) (AA 177-189) antibody
anti-Parkinson Protein 7 (PARK7) (AA 177-189) antibody (2) anti-Parkinson Protein 7 (PARK7) (AA 177-189) antibody (Image 2)
Background publications Taira, Takahashi, Kitagawa et al.: "Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter." in: Gene, Vol. 263, Issue 1-2, pp. 285-92, 2001 (PubMed).

van Duijn, Dekker, Bonifati et al.: "Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36." in: American journal of human genetics, Vol. 69, Issue 3, pp. 629-34, 2001 (PubMed).

Bonifati, Rizzu, van Baren et al.: "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism." in: Science (New York, N.Y.), Vol. 299, Issue 5604, pp. 256-9, 2003 (PubMed).

Niki, Takahashi-Niki, Taira et al.: "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex." in: Molecular cancer research : MCR, Vol. 1, Issue 4, pp. 247-61, 2003 (PubMed).

Takahashi-Niki, Niki, Taira et al.: "Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients." in: Biochemical and biophysical research communications, Vol. 320, Issue 2, pp. 389-97, 2004 (PubMed).

Validation Images
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