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AHA1, Activator of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) (AHSA1) (Internal Region) antibody

Details for Product No. ABIN401377
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Antigen
Synonyms p38, AHA1, C14orf3, ahsa1, MGC52884, MGC132147, MGC80312, AHSA1, MGC89589, wu:fb83b05, zgc:136821, zgc:56075
Epitope
Internal Region
(8), (6), (4), (4), (4), (1), (1), (1), (1), (1), (1)
Reactivity
Chimpanzee, Human
(87), (81), (16), (1), (1)
Host
Rabbit
(69), (50), (26)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3)
Application
ELISA, Western Blotting (WB)
(142), (126), (75), (71), (69), (52), (12), (4), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN401377
390.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to an internal region of human AHA1 protein
Isotype IgG
Specificity This antibody is directed against AHA1 protein.
Purification Affinity chromatography
Alternative Name AHA1 / AHSA1
Background Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist clientprotein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa 370–390) of Hsp90 that exposes the catalytic Arg380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone. Recent studies show that AHA1 modulates Hsp90-dependent stability of the folding of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum (ER). Down-regulation of AHA1 rescues misfolding of CFTR in cystic fibrosis.
Alternate names: Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322
Gene ID 10598
NCBI Accession NP_036243.1
UniProt O95433
Application Notes ELISA: 1/35,000 - 1/185,000. Western Blot: 1/500 - 1/3,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.08 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-AHA1, Activator of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) (AHSA1) (Internal Region) antibody anti-AHA1, Activator of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) (AHSA1) (Internal Region) antibody
Background publications Panaretou, Siligardi, Meyer et al.: "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1." in: Molecular cell, Vol. 10, Issue 6, pp. 1307-18, 2002 (PubMed).

Wang, Venable, LaPointe et al.: "Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis." in: Cell, Vol. 127, Issue 4, pp. 803-15, 2006 (PubMed).

Hosts (69), (50), (26)
Reactivities (87), (81), (16), (1), (1)
Applications (142), (126), (75), (71), (69), (52), (12), (4), (1)
Conjugates (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3)
Epitopes (8), (6), (4), (4), (4), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN401377
390.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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