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Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer170) antibody

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Synonyms marcks, MGC89127, MARCKS, Macs, PKCSL, KINC, macs, wu:fb55c06, wu:fb92d04, wu:fc19b04, wu:fc44a10, zgc:110235, 80K-L, MACS, PRKCSL
(31), (28), (27), (26), (25), (17), (10), (10), (7), (6), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(208), (121), (114), (11), (10), (4), (4), (3), (3), (1)
(215), (14), (2)
(4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(175), (63), (60), (40), (26), (26), (11), (5), (2), (2), (2), (1)
Pubmed 4 references available
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Quantity 0.1 mL
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Availability Will be delivered in 6 to 8 Business Days
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human MARCKS around the phosphorylation site of Serine 170 (G-F-Sp-F-K).
Specificity This antibody detects endogenous levels of MARCKS only when phosphorylated at Threonine 170.
Purification Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name MARCKS (MARCKS Antibody Abstract)
Background MARCKS, (Myristoylated Alanine-Rich C Kinase Substrate), is a member of a family of calmodulin binding proteins and is a major substrate for phosphorylation by protein kinase C (PKC). The phosphorylation of Ser152/156 can be used as a measure of PKC activation. Phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin.Synonyms: MACS, Myristoylated alanine-rich C-kinase substrate, PRKCSL
Gene ID 4082
NCBI Accession NP_002347
UniProt P29966
Research Area Cardiovascular
Application Notes Western blot: 1/500approx. 1/1000. Immunohistochemistry on Paraffin Sections: 1/50approx. 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.
Supplier Images
 image for anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer170) antibody (ABIN401558) anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer170) antibody
 image for anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer170) antibody (ABIN401558) anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer170) antibody (Image 2)
Background publications Ramsden: "MARCKS: a case of molecular exaptation?" in: The international journal of biochemistry & cell biology, Vol. 32, Issue 5, pp. 475-9, 2001 (PubMed).

Graff, Young, Johnson et al.: "Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C." in: The Journal of biological chemistry, Vol. 264, Issue 36, pp. 21818-23, 1990 (PubMed).

Thelen, Rosen, Nairn et al.: "Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane." in: Nature, Vol. 351, Issue 6324, pp. 320-2, 1991 (PubMed).

Hartwig, Thelen, Rosen et al.: "MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin." in: Nature, Vol. 356, Issue 6370, pp. 618-22, 1992 (PubMed).

Catalog No. ABIN401558
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