PARP11 antibody (Middle Region)

Catalog No. ABIN404898

Product Details anti-PARP11 Antibody

Target: PARP11 (Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP11 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IKHGNTFQIH GVSLQQRHLF RTYKSMFLAR VLIGDYINGD SKYMRPPSKD

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PARP11. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PARP11

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 331 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PARP11

Target: PARP11 (Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))

Alternative Name: PARP11 (PARP11 Products)

Synonyms: 5330431N24Rik antibody, AI851877 antibody, ARTD11 antibody, HIN1L antibody, C12orf6 antibody, parp11 antibody, MGC82612 antibody, PARP11 antibody, RGD1561791 antibody, poly (ADP-ribose) polymerase family, member 11 antibody, poly(ADP-ribose) polymerase family member 11 antibody, poly(ADP-ribose) polymerase family member 11 S homeolog antibody, poly(ADP-ribose) polymerase family member 11 L homeolog antibody, Parp11 antibody, PARP11 antibody, parp11.S antibody, parp11.L antibody, parp11 antibody

Background: PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.
Alias Symbols: C12orf6, DKFZp779H0122
Protein Interaction Partner: MDFI, TRIP13, DCAF11, RNF114, OTUD4, LYZ, GTPBP3, NUP98,
Protein Size: 331

Molecular Weight: 39 kDa

Gene ID: 57097

NCBI Accession: NM_020367, NP_065100

UniProt: Q9NR21