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Details for Product No. ABIN405112

One Cut Homeobox 2 (ONECUT2) (N-Term) antibody

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Antigen
Synonyms OC-2, OC2, C730009D12, Oc2, RGD1564677
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN405112
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-ONECUT2 antibody: synthetic peptide directed towards the N terminal of human ONECUT2
Sequence TSMASILDGGDYRPELSIPLHHAMSMSCDSSPPGMGMSNT YTTLTPLQPL
Predicted Reactivity Guinea pig : 100%, Pig : 100%, Mouse : 92%
Characteristics This is a rabbit polyclonal antibody against ONECUT2. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name ONECUT2
Background ONECUT2 is a member of the transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF)-6. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. ONECUT2 participates in the network of transcription factors required for liver differentiation and metabolism. This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation.
Molecular Weight 54kDa
Gene ID 9480
NCBI Accession NP_004843, NM_004852
UniProt O95948
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-ONECUT2 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Rauch, Li, Wu et al.: "MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells." in: Cancer research, Vol. 66, Issue 16, pp. 7939-47, 2006 (PubMed).

Alternatives for antigen "One Cut Homeobox 2 (ONECUT2)", type "Antibodies"
Hosts (8), (1)
Reactivities (8), (3), (1), (1), (1)
Applications (8), (2), (2), (1), (1), (1)
Epitopes (4), (2), (2), (2), (1)
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