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Myeloid Cell Nuclear Differentiation Antigen (MNDA) (C-Term) antibody

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Synonyms PYHIN3, A730048F03, Ifi205b
(18), (16), (10), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(49), (8), (2)
(3), (2), (2), (2), (2), (2)
Western Blotting (WB)
(46), (33), (22), (19), (10), (4), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the C terminal of human MNDA
Blocking Peptide Blocking peptide for this product available: ABIN980169
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against MNDA. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MNDA (MNDA Antibody Abstract)
Background The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage.MNDA may act as a transcriptional activator/repressor in the myeloid lineage. It plays a role in the granulocyte/monocyte cell-specific response to interferon. MNDA stimulates the DNA binding of the transcriptional repressor protein YY1.The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.
Molecular Weight 46 kDa
Gene ID 4332
NCBI Accession NP_002423, NM_002432
UniProt P41218
Research Area Stem Cells, Hematopoietic Progenitors, Innate Immunity, Cytokines
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 407 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Myeloid Cell Nuclear Differentiation Antigen (MNDA) (C-Term) antibody (ABIN405140) anti-Myeloid Cell Nuclear Differentiation Antigen (MNDA) (C-Term) antibody
Background publications Briggs, Shults, Flye et al.: "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis." in: Cancer research, Vol. 66, Issue 9, pp. 4645-51, 2006 (PubMed).

Catalog No. ABIN405140
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