Myeloid Cell Nuclear Differentiation Antigen (MNDA) (C-Term) antibody

Details for Product No. ABIN405140
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Antigen
Synonyms PYHIN3, A730048F03, Ifi205b
Epitope
C-Term
(6), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(32)
Host
Rabbit
(23), (5), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2)
Application
Western Blotting (WB)
(25), (17), (8), (7), (4), (3), (2), (2), (2), (2)
Pubmed 1 reference available
Catalog no. ABIN405140
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the C terminal of human MNDA
Sequence KCEKGDKLRLFCLQLRTVDRKLKLVCGSHSFIKVIKAKKN KEGPMNVN
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against MNDA. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MNDA
Background The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage.MNDA may act as a transcriptional activator/repressor in the myeloid lineage. It plays a role in the granulocyte/monocyte cell-specific response to interferon. MNDA stimulates the DNA binding of the transcriptional repressor protein YY1.The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.
Molecular Weight 46 kDa
Gene ID 4332
NCBI Accession NM_002432, NP_002423
UniProt P41218
Research Area Stem Cells, Hematopoietic Progenitors, Innate Immunity, Cytokines
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 407 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Briggs, Shults, Flye et al.: "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis." in: Cancer research, Vol. 66, Issue 9, pp. 4645-51, 2006 (PubMed).

Hosts (23), (5), (4)
Reactivities (32)
Applications (25), (17), (8), (7), (4), (3), (2), (2), (2), (2)
Conjugates (2)
Epitopes (6), (3), (2), (2), (2), (1), (1), (1), (1)
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