Lysine (K)-Specific Demethylase 6A (KDM6A) (Middle Region) antibody

Details for Product No. ABIN405243
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Antigen
Synonyms KABUK2, UTX, bA386N14.2, Utx, RGD1565481, Uty
Epitope
Middle Region
(4), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Human
(12), (2)
Host
Rabbit
(8), (4)
Clonality
Polyclonal
Application
Western Blotting (WB)
(12), (4), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN405243
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Immunogen Synthetic peptide directed towards the middle region of human UTX
Sequence KTYIVHCQDC ARKTSGNLEN FVVLEQYKME DLMQVYDQFT LAPPLPSASS
Predicted Reactivity Human : 100 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against UTX. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name UTX
Background UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Molecular Weight 154 kDa
Gene ID 7403
NCBI Accession NP_066963, NM_021140
UniProt O15550
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1401 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Lysine (K)-Specific Demethylase 6A (KDM6A) (Middle Region) antibody WB Suggested Anti-UTX Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: MCF7 cell lysate
Background publications Hong, Cho, Yu et al.: "Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 47, pp. 18439-44, 2007 (PubMed).

Validation Images
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