Membrane Protein, Palmitoylated 7 (MAGUK p55 Subfamily Member 7) (MPP7) (N-Term) antibody

Details for Product No. ABIN406339
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Antigen
Synonyms 1110068J02Rik, 2810038M04Rik, 5430426E14Rik, AI415104, Gm955, dlg3, hmp
Epitope
N-Term
(4), (2), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human, Chicken
(12), (5), (5)
Host
Rabbit
(10), (2)
Clonality
Polyclonal
Application
Western Blotting (WB)
(12), (5), (3), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN406339
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Immunogen Synthetic peptide directed towards the N terminal of human MPP7
Sequence MPALSTGSGS DTGLYELLAA LPAQLQPHVD SQEDLTFLWD MFGEKSLHSL
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against MPP7. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MPP7
Background MPP7 acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. MPP7 is involved in the assembly of protein complexes at sites of cell-cell contact.Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein complexes at sites of cell-cell contact. They are found in synapses, adherens junctions, and tight junctions. All MAGUKs contain at least 1 PDZ domain, an SH3 domain, and a GUK domain, and many contain 1 or 2 L27 domains, which are involved in multimerization of MAGUKs. MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named for a Drosophila gene required for establishment of cell polarity in the developing fly embryo (Bohl et al., 2007 [PubMed 17237226]).
Molecular Weight 65 kDa
Gene ID 143098
NCBI Accession NP_775767, NM_173496
UniProt Q5T2T1
Research Area Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 576 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Membrane Protein, Palmitoylated 7 (MAGUK p55 Subfamily Member 7) (MPP7) (N-Term) antibody WB Suggested Anti-MPP7 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HT1080 cell lysate
Product cited in: Stucke, Timmerman, Vandekerckhove et al.: "The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation." in: Molecular biology of the cell, Vol. 18, Issue 5, pp. 1744-55, 2007 (PubMed).

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