HtrA Serine Peptidase 4 (HTRA4) (Middle Region) antibody

Details for Product No. ABIN406558
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Antigen
Synonyms B430206E18Rik, RGD1306242
Epitope
Middle Region
(9), (7), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(15), (2), (2)
Host
Rabbit
(14), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(15), (8), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN406558
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human HTRA4
Sequence LKMHYPDFPD VSSGVYVCKV VEGTAAQSSG LRDHDVIVNI NGKPITTTTD
Predicted Reactivity Human : 100 %, Dog : 90 %, Horse : 90 %, Pig : 90 %, Rabbit : 90 %, Bovine : 80 %, Guinea pig : 80 %, Mouse : 80 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against HTRA4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HTRA4
Background HTRA4 is a member of the HtrA family of proteases. The protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
Molecular Weight 51 kDa
Gene ID 203100
NCBI Accession NP_710159, NM_153692
UniProt P83105
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 476 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-HtrA Serine Peptidase 4 (HTRA4) (Middle Region) antibody WB Suggested Anti-HTRA4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human brain
Background publications Clausen, Southan, Ehrmann: "The HtrA family of proteases: implications for protein composition and cell fate." in: Molecular cell, Vol. 10, Issue 3, pp. 443-55, 2002 (PubMed).

Validation Images
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