HtrA Serine Peptidase 4 (HTRA4) (Middle Region) antibody

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Antigen
Synonyms B430206E18Rik, RGD1306242
Epitope
Middle Region
(17), (14), (10), (2), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(30), (4), (4)
Host
Rabbit
(27), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(27), (19), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human HTRA4
Blocking Peptide Blocking peptide for this product available: HtrA Serine Peptidase 4 (HTRA4) (Middle Region) peptide (ABIN978360)
Sequence LKMHYPDFPD VSSGVYVCKV VEGTAAQSSG LRDHDVIVNI NGKPITTTTD
Predicted Reactivity Human : 100 %, Dog : 90 %, Horse : 90 %, Pig : 90 %, Rabbit : 90 %, Bovine : 80 %, Guinea pig : 80 %, Mouse : 80 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against HTRA4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HTRA4 (HTRA4 Antibody Abstract)
Background HTRA4 is a member of the HtrA family of proteases. The protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
Molecular Weight 51 kDa
Gene ID 203100
NCBI Accession NP_710159, NM_153692
UniProt P83105
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 476 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-HtrA Serine Peptidase 4 (HTRA4) (Middle Region) antibody (ABIN406558) WB Suggested Anti-HTRA4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Clausen, Southan, Ehrmann: "The HtrA family of proteases: implications for protein composition and cell fate." in: Molecular cell, Vol. 10, Issue 3, pp. 443-55, 2002 (PubMed).

Catalog No. ABIN406558
$289.00
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