AHA1, Activator of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) (AHSA1) (N-Term) antibody

Details for Product No. ABIN452726
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Antigen
Synonyms ahsa1, MGC52884, MGC132147, MGC80312, AHSA1, MGC89589, wu:fb83b05, zgc:136821, zgc:56075, AHA1, C14orf3, p38, BC023857
Epitope
N-Term
(7), (7), (6), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(99), (81), (14), (6), (1)
Host
Rabbit
(79), (52), (26)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(154), (134), (77), (75), (67), (54), (15), (5), (5), (4), (2)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN452726
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Immunogen KLH conjugated synthetic peptide selected from the N-terminal region of human AHSA1
Specificity This antibody detects AHA1 / AHSA1 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name AHA1 / AHSA1
Background AHA1 is a member of the HSP90 co-chaperone family. AHA1 is thought to stimulate HSP90 ATPase activity by competing with p23 and other cochaperones for Hsp90 binding. It may affect a step in the endoplasmic reticulum to Golgi trafficking. AHA1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV G). AHA1 is expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.Synonyms: Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322
Molecular Weight 38274 Da
Gene ID 10598
NCBI Accession NP_036243
UniProt O95433
Application Notes Western blot: 1: 50 - 1: 100. ELISA: 1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-AHA1, Activator of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) (AHSA1) (N-Term) antibody anti-AHA1, Activator of Heat Shock 90kDa Protein ATPase Homolog 1 (Yeast) (AHSA1) (N-Term) antibody
Background publications Wang, Venable, LaPointe et al.: "Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis." in: Cell, Vol. 127, Issue 4, pp. 803-15, 2006 (PubMed).

Panaretou, Siligardi, Meyer et al.: "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1." in: Molecular cell, Vol. 10, Issue 6, pp. 1307-18, 2002 (PubMed).

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