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Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (N-Term) antibody

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Synonyms CKIP-1, OC120, 2810052M02Rik, Ckip1, JZA-20, Jza2, RGD1311487
(13), (13), (9), (5), (4), (3), (2), (1), (1)
(45), (25), (25)
(39), (6)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(30), (21), (12), (11), (9), (5), (2), (2)
Pubmed 1 reference available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide selected from the N-terminal region of human CKIP-1
Specificity This antibody detects CKIP-1 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name PLEKHO1 / CKIP1 (PLEKHO1 Antibody Abstract)
Background CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). This protein may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). It appears to target ATM to the plasma membrane and appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.Synonyms: C-Jun-binding protein, CK2-interacting protein 1, CKIP-1, Casein kinase 2-interacting protein 1, HQ0024c, JBP, OC120, Osteoclast maturation-associated gene 120 protein, PH domain-containing family O member 1, Pleckstrin homology domain-containing family O member 1
Molecular Weight 46237 Da
Gene ID 51177
NCBI Accession NP_057358
UniProt Q53GL0
Application Notes Western blot: 1: 50 - 1: 100. ELISA: 1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (N-Term) antibody (ABIN452845) anti-Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) (N-Term) antibody
Background publications Barrios-Rodiles, Brown, Ozdamar et al.: "High-throughput mapping of a dynamic signaling network in mammalian cells." in: Science (New York, N.Y.), Vol. 307, Issue 5715, pp. 1621-5, 2005 (PubMed).

Catalog No. ABIN452845
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