Ribonucleotide Reductase M2 (RRM2) (Middle Region) antibody

Details for Product No. ABIN453352
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Antigen
Synonyms R2, RR2, RR2M, AA407299, cb111, chunp6884, r2, RRM2, rrm2, rr2m
Epitope
Middle Region
(3), (3), (2), (2), (1)
Reactivity
Human
(35), (15), (15), (13), (13), (13), (2), (2)
Host
Rabbit
(31), (8), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(28), (13), (10), (10), (6), (4), (3), (1), (1)
Pubmed 2 references available
Catalog no. ABIN453352
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide selected from the Center region of human RRM2
Specificity This antibody reacts to RRM2.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name RRM2 / RR2
Background RRM2 is one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the protein (M2) is regulated in a cell-cycle dependent fashion.
Alternate names: Ribonucleoside-diphosphate reductase subunit M2, Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit
Gene ID 6241
NCBI Accession NP_001025
UniProt P31350
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Kolesar, Huang, Eickhoff et al.: "Evaluation of mRNA by Q-RTPCR and protein expression by AQUA of the M2 subunit of ribonucleotide reductase (RRM2) in human tumors." in: Cancer chemotherapy and pharmacology, Vol. 64, Issue 1, pp. 79-86, 2009 (PubMed).

Liu, Xue, Yen: "Redox property of ribonucleotide reductase small subunit M2 and p53R2." in: Methods in molecular biology (Clifton, N.J.), Vol. 477, pp. 195-206, 2008 (PubMed).

Hosts (31), (8), (1)
Reactivities (35), (15), (15), (13), (13), (13), (2), (2)
Applications (28), (13), (10), (10), (6), (4), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (2), (2), (1)
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