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Details for Product No. ABIN453818

Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (Middle Region) antibody

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Antigen
Synonyms BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1, ENaC, Scnn1, mENaC, SCNN1A, alphaxENaC, besc2, enaca, scnn1, ENAC
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN453818
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days

Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen KLH conjugated synthetic peptide selected from the Center region of human SCNN1A
Specificity This antibody reacts to SCNN1A.
Purification Affinity chromatography on Protein A

Target Details

Application Details Handling References Alternatives back to top
Alternative Name ENAC alpha / SCNN1A
Background Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.
Alternate names: Alpha-ENaC, Alpha-NaCH, Amiloride-sensitive sodium channel subunit alpha, ENaCA, Epithelial Na(+) channel subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, SCNN1
Gene ID 6337
NCBI Accession NP_001029
UniProt P37088
Research Area Ion Channels

Application Details

Target Details Handling References Alternatives back to top
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months

References

Target Details Application Details Handling Alternatives back to top
Background publications Azad, Rauh, Vermeulen et al.: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, 2009 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A)", type "Antibodies"
Hosts (32), (1)
Reactivities (28), (24), (21), (17), (17), (17)
Applications (17), (17), (10), (8), (6), (5), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (2), (2), (1), (1), (1), (1), (1)
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