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Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (Middle Region) antibody

Details for Product No. ABIN453818, Supplier: Login to see
Antigen
  • SCNN1A
  • ENaCalpha
  • BESC2
  • ENaCa
  • SCNEA
  • SCNN1
  • alphaxENaC
  • besc2
  • enaca
  • scnn1
  • ENaC
  • Scnn1
  • mENaC
  • ENAC
Epitope
Middle Region
20
18
16
11
6
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
44
32
11
Host
Rabbit
68
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
54
30
23
19
7
3
2
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide selected from the Center region of human SCNN1A
Specificity This antibody reacts to SCNN1A.
Purification Affinity chromatography on Protein A
Alternative Name ENAC alpha / SCNN1A (SCNN1A Antibody Abstract)
Background Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.Synonyms: Alpha-ENaC, Alpha-NaCH, Amiloride-sensitive sodium channel subunit alpha, ENaCA, Epithelial Na(+) channel subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, SCNN1
Gene ID 6337
NCBI Accession NP_001029
UniProt P37088
Research Area Ion Channels
Pathways
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (Middle Region) antibody (ABIN453818) Western blot analysis of SCNN1A Antibody (Center) in WiDr cell line lysates (35ug/lan...
Background publications Azad, Rauh, Vermeulen et al.: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, 2009 (PubMed).