Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (Middle Region) antibody

Details for Product No. ABIN453818
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Antigen
Synonyms SCNN1A, ENaCalpha, BESC2, ENaCa, SCNEA, SCNN1, alphaxENaC, besc2, enaca, scnn1, ENaC, Scnn1, mENaC, ENAC
Epitope
Middle Region
(20), (18), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(39), (37), (18), (12), (12), (12)
Host
Rabbit
(59), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(45), (29), (19), (12), (10), (6), (3), (1)
Pubmed 1 reference available
Quantity 0.4 mL
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Catalog No. ABIN453818
357.50 $
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Immunogen KLH conjugated synthetic peptide selected from the Center region of human SCNN1A
Specificity This antibody reacts to SCNN1A.
Purification Affinity chromatography on Protein A
Alternative Name ENAC alpha / SCNN1A
Background Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.Synonyms: Alpha-ENaC, Alpha-NaCH, Amiloride-sensitive sodium channel subunit alpha, ENaCA, Epithelial Na(+) channel subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, SCNN1
Gene ID 6337
NCBI Accession NP_001029
UniProt P37088
Research Area Ion Channels
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Azad, Rauh, Vermeulen et al.: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, 2009 (PubMed).

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