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E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3) (Middle Region) antibody

Details for Product No. ABIN486862
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Antigen
Synonyms ERT, ESX, EPR-1, ESE-1, jen, ef2, elf2, zef2, ELF2, wu:fb06f04, ELF4, ELF3, DKFZp469F2239, ert, esx, epr-1, ese-1
Epitope
Middle Region
(21), (7), (7), (6), (5), (4), (3), (2), (2), (1), (1)
Reactivity
Cow (Bovine), Human
(70), (20), (16), (14), (13)
Host
Rabbit
(50), (21), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(64), (40), (10), (9), (4), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
Options
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN486862
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide directed towards the middle region of human Elf3
Sequence GSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDP TDGKLFPSDG
Predicted Reactivity Human : 100 %, Rabbit : 100 %, Pig : 90 %, Bovine : 80 %
Characteristics This is a rabbit polyclonal antibody against ELF3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name Elf3
Background ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Molecular Weight 41 kDa
Gene ID 1999
NCBI Accession NM_004433, NP_004424
UniProt P78545
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 371 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3) (Middle Region) antibody WB Suggested Anti-Elf3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: MCF7 cell lysate
Background publications Peng, Tan, Osaki et al.: "ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes." in: Journal of cellular physiology, Vol. 215, Issue 2, pp. 562-73, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN486862
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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