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Details for Product No. ABIN486862

E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3) (Middle Region) antibody

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Antigen
Synonyms ERT, ESX, EPR-1, ESE-1, jen, ef2, elf2, zef2, ELF2, wu:fb06f04, ELF4, ELF3, DKFZp469F2239, ert, esx, epr-1, ese-1
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Cow (Bovine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN486862
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-Elf3 antibody: synthetic peptide directed towards the middle region of human Elf3
Sequence GSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDP TDGKLFPSDG
Predicted Reactivity Human : 100%, Rabbit : 100%, Pig : 92%, Bovine : 85%
Characteristics This is a rabbit polyclonal antibody against ELF3. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name Elf3
Background ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Molecular Weight 41kDa
Gene ID 1999
NCBI Accession NP_004424, NM_004433
UniProt P78545
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-Elf3 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Peng, Tan, Osaki et al.: "ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes." in: Journal of cellular physiology, Vol. 215, Issue 2, pp. 562-73, 2008 (PubMed).

Alternatives for antigen "E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3)", type "Antibodies"
Hosts (40), (15), (7)
Reactivities (54), (21), (16), (14), (13)
Applications (49), (26), (10), (4), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (7), (7), (4), (3), (2), (1), (1), (1), (1), (1)
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