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Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (Middle Region) antibody

Details for Product No. ABIN487122, Supplier: Login to see New
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Synonyms BMIQ12, NEC1, PC1, PC3, SPC3, BDP, Nec-1, Nec1, Phpp-1, PC1/3
Middle Region
(6), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Cow (Bovine), Dog (Canine), Human, Pig (Porcine), Rat (Rattus)
(28), (7), (7), (2)
(19), (12)
Immunohistochemistry (IHC), Western Blotting (WB)
(28), (12), (11), (9), (5), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the middle region of human PCSK1
Blocking Peptide Blocking peptide for this product available: ABIN981479
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Pig : 90 %, Rabbit : 90 %
Characteristics This is a rabbit polyclonal antibody against PCSK1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PCSK1 (PCSK1 Antibody Abstract)
Background PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
Molecular Weight 71 kDa
Gene ID 5122
NCBI Accession NM_000439, NP_000430
UniProt P29120
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 753 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Immunohistochemistry (IHC) image for anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (Middle Region) antibody (ABIN487122) Immunohistochemistry with Pancreas tissue at an antibody concentration of 5µg/ml usin...
Background publications Rehfeld, Bundgaard, Hannibal et al.: "The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6." in: Endocrinology, Vol. 149, Issue 4, pp. 1600-8, 2008 (PubMed).

Catalog No. ABIN487122
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