Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (Middle Region) antibody

Details for Product No. ABIN487122
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Antigen
Synonyms BMIQ12, NEC1, PC1, PC3, SPC3, BDP, Nec-1, Nec1, Phpp-1, PC1/3
Epitope
Middle Region
(4), (3), (3), (2), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Dog (Canine), Cow (Bovine), Pig (Porcine), Human
(19), (6), (6), (1), (1)
Host
Rabbit
(14), (7)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(17), (9), (7), (5), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN487122
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Immunogen Synthetic peptide directed towards the middle region of human PCSK1
Sequence QSPKKSPSAK LNIPYENFYE ALEKLNKPSQ LKDSEDSLYN DYVDVFYNTK
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Pig : 90 %, Rabbit : 90 %
Characteristics This is a rabbit polyclonal antibody against PCSK1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PCSK1
Background PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
Molecular Weight 71 kDa
Gene ID 5122
NCBI Accession NM_000439, NP_000430
UniProt P29120
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 753 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (Middle Region) antibody Immunohistochemistry with Pancreas tissue at an antibody concentration of 5µg/ml using anti-PCSK1 antibody (ARP33848_P050)
Background publications Rehfeld, Bundgaard, Hannibal et al.: "The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6." in: Endocrinology, Vol. 149, Issue 4, pp. 1600-8, 2008 (PubMed).

Validation Images
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