SPINK1 antibody (N-Term)

Catalog No. ABIN487126

Product Details anti-SPINK1 Antibody

Target: SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))

Binding Specificity: N-Term

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPINK1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KVTGIFLLSA LALLSLSGNT GADSLGREAK CYNELNGCTK IYDPVCGTDG

Predicted Reactivity: Human: 100%, Rabbit: 93%

Characteristics: This is a rabbit polyclonal antibody against SPINK1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPINK1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 79 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SPINK1 antibody (ABIN487126)

Tomlins, Rhodes, Yu, Varambally, Mehra, Perner, Demichelis, Helgeson, Laxman, Morris, Cao, Cao, Andrén, Fall, Johnson, Wei, Shah, Al-Ahmadie, Eastham, Eggener, Fine, Hotakainen, Stenman, Tsodikov et al.: "The role of SPINK1 in ETS rearrangement-negative prostate cancers. ..." in: Cancer cell, Vol. 13, Issue 6, pp. 519-28, (2008) (PubMed).

Target Details for SPINK1

Target: SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))

Alternative Name: SPINK1 (SPINK1 Products)

Synonyms: PCTT antibody, PSTI antibody, Spink3 antibody, TATI antibody, TCP antibody, Psti antibody, SPINK1 antibody, p12 antibody, serine peptidase inhibitor, Kazal type 1 antibody, SPINK1 antibody, Spink1 antibody

Background: SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
Alias Symbols: PCTT, PSTI, Spink3, TATI, TCP
Protein Interaction Partner: NRSN1, TMPRSS15, CTRC, ELN,
Protein Size: 79

Molecular Weight: 8 kDa

Gene ID: 6690

NCBI Accession: NM_003122, NP_003113

UniProt: P00995