Cell Division Cycle 16 Homolog (S. Cerevisiae) (CDC16) (N-Term) antibody

Details for Product No. ABIN499301
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Antigen
Synonyms zgc:123264, F9K20.19, F9K20_19, anaphase promoting complex 6, 2700071J12Rik, 2810431D22Rik, APC6, ANAPC6, CUT9
Epitope
N-Term
(17), (17), (9), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(87), (51), (30), (22), (22), (11)
Host
Rabbit
(87)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
ELISA, Western Blotting (WB)
(59), (45), (28), (27), (17), (14), (4), (3), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN499301
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Immunogen APC6 antibody was raised against an 18 amino acid peptide near the amino terminus of human APC6.
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name CDC16 / APC6
Background Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle- associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.
Alternate names: ANAPC6, Anaphase-promoting complex subunit 6, CDC16Hs, Cell division cycle protein 16 homolog, Cyclosome subunit 6
Gene ID 8881
NCBI Accession NP_003894
UniProt Q13042
Research Area Coagulation
Application Notes ELISA. Western Blot: APC6 antibody can be used for detection of APC6 at 1 - 2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Jörgensen, Gräslund, Betz et al.: "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex." in: Gene, Vol. 262, Issue 1-2, pp. 51-9, 2001 (PubMed).

Peters: "The anaphase promoting complex/cyclosome: a machine designed to destroy." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 644-56, 2006 (PubMed).

Wang, Dye, Rajashankar et al.: "Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure." in: Nature structural & molecular biology, Vol. 16, Issue 9, pp. 987-9, 2009 (PubMed).

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