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SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibody

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Synonyms im:5777505, wu:fa08f03, wu:fb13e12, MGC79086, sh3glb1, wu:fc55h11, wu:fj98d09, AA409932, AI314629, AU015566, Bif-1, mKIAA0491, PPP1R70, dJ612B15.2
(24), (12), (7), (7), (5), (4), (4), (4), (2), (2), (1), (1)
Human, Mouse (Murine)
(100), (33), (29), (2), (1), (1), (1), (1), (1)
(77), (16), (8), (1)
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(74), (42), (38), (23), (11), (9), (5), (5), (2), (2)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen BIF antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human BIF.
Isotype IgG
Specificity This anitbody reacts to BIF.
Purification Affinity chromatography purified via peptide column
Alternative Name Endophilin-B1 (SH3GLB1 Antibody Abstract)
Background Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family such as Bax appear to control the activation of these enzymes. Bax activity was found to be regulated by its association with Bax-interacting factor 1 (BIF), a member of the endophilin B family that is associated with intracellular membranes.. Following this interaction, Bax undergoes a conformational change and translocates to mitochondrial membranes. The Bax/BIF interaction appears to be enhanced by apoptotic stimuli, suggesting that BIF acts as the trigger to activate Bax, and as suppression of BIF promoted HeLa cell colony formation in soft agar, it may have a role in the suppression of cancer progression. At least two isoforms of BIF are known to exist.Synonyms: BIF1, Bax-interacting factor 1, Bif-1, KIAA0491, SH3 domain-containing GRB2-like protein B1, SH3GLB1
Gene ID 51100
UniProt Q9Y371
Application Notes ELISA. Western BLot: BIF antibody can be used for the detection of BIF at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunofluorescence (IF) image for anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibody (ABIN499465) Immunocytochemistry of BIF in HeLa with AP30149PU-N BIF antibody at 10 μg/ml.
Western Blotting (WB) image for anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibody (ABIN499465) Western blot analysis of BIF in HeLa cell lysate with AP30149PU-N BIF antibody at (A)...
Background publications Takahashi, Karbowski, Yamaguchi et al.: "Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9369-82, 2005 (PubMed).

Cuddeback, Yamaguchi, Komatsu et al.: "Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 20559-65, 2001 (PubMed).

Lockshin, Osborne, Zakeri: "Cell death in the third millennium." in: Cell death and differentiation, Vol. 7, Issue 1, pp. 2-7, 2000 (PubMed).

Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).

Catalog No. ABIN499465
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