Dapper, Antagonist of beta-Catenin, Homolog 3 (Xenopus Laevis) (DACT3) (N-Term) antibody

Details for Product No. ABIN499704
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms RGD1563892, EG666671, naa-3, DAPPER3, RRR1
Epitope
N-Term
(14), (7), (5), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(43), (22), (18), (12), (12)
Host
Rabbit
(25), (18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(27), (22), (10), (6), (4)
Pubmed 4 references available
Catalog no. ABIN499704
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Dact3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Dact3. (AP30270CP-N)
Isotype IgG
Specificity This antibody reacts to DACT3.
Purification Affinity chromatography purified via peptide column
Alternative Name DACT3
Background The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/b-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.
Alternate names: DAPPER3, RRR1, antagonist of beta-catenin dapper homolog 3, arginine-rich region 1 protein, dapper homolog 3
Gene ID 147906
NCBI Accession Q96B18
UniProt Q96B18
Research Area Signaling
Application Notes ELISA. Western Blot: 1 – 2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Cheyette, Waxman, Miller et al.: "Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation." in: Developmental cell, Vol. 2, Issue 4, pp. 449-61, 2002 (PubMed).

Katoh, Katoh: "Identification and characterization of human DAPPER1 and DAPPER2 genes in silico." in: International journal of oncology, Vol. 22, Issue 4, pp. 907-13, 2003 (PubMed).

Shimogori, VanSant, Paik et al.: "Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex." in: The Journal of comparative neurology, Vol. 473, Issue 4, pp. 496-510, 2004 (PubMed).

Fisher, Kivimäe, Hoshino et al.: "Three Dact gene family members are expressed during embryonic development and in the adult brains of mice." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 235, Issue 9, pp. 2620-30, 2006 (PubMed).

Hosts (25), (18)
Reactivities (43), (22), (18), (12), (12)
Applications (27), (22), (10), (6), (4)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (7), (5), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top