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Dapper, Antagonist of beta-Catenin, Homolog 3 (Xenopus Laevis) (DACT3) (N-Term) antibody

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Synonyms EG666671, naa-3, DAPPER3, RRR1, RGD1563892
(22), (15), (6), (2), (2), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(56), (22), (20)
(44), (12)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(41), (29), (11), (4), (4), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Dact3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Dact3.
Isotype IgG
Specificity This antibody reacts to DACT3.
Purification Affinity chromatography purified via peptide column
Alternative Name DACT3
Background The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/b-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.Synonyms: DAPPER3, RRR1, antagonist of beta-catenin dapper homolog 3, arginine-rich region 1 protein, dapper homolog 3
Gene ID 147906
UniProt Q96B18
Research Area Signaling
Application Notes ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Western Blotting (WB) image for anti-Dapper, Antagonist of beta-Catenin, Homolog 3 (Xenopus Laevis) (DACT3) (N-Term) antibody (ABIN499704) Western blot analysis of Dact3 in rat brain tissue lysate with AP30270PU-N Dact3 anti...
Background publications Fisher, Kivimäe, Hoshino et al.: "Three Dact gene family members are expressed during embryonic development and in the adult brains of mice." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 235, Issue 9, pp. 2620-30, 2006 (PubMed).

Shimogori, VanSant, Paik et al.: "Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex." in: The Journal of comparative neurology, Vol. 473, Issue 4, pp. 496-510, 2004 (PubMed).

Katoh, Katoh: "Identification and characterization of human DAPPER1 and DAPPER2 genes in silico." in: International journal of oncology, Vol. 22, Issue 4, pp. 907-13, 2003 (PubMed).

Cheyette, Waxman, Miller et al.: "Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation." in: Developmental cell, Vol. 2, Issue 4, pp. 449-61, 2002 (PubMed).

Catalog No. ABIN499704
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