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Duffy Blood Group, Chemokine Receptor (DARC) (N-Term) antibody

Details for Product No. ABIN499712
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Antigen
Synonyms DARC, FY, ACKR1, CCBP1, CD234, Dfy, GPD, GpFy, WBCQ1, AA162249, Ackr1, ESTM35
Epitope
N-Term
(27), (13), (8), (4), (1), (1), (1), (1)
Reactivity
Human
(64), (27), (23)
Host
Rabbit
(62), (7), (7), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(54), (43), (24), (15), (15), (9), (9), (5), (4), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN499712
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Immunogen DARC antibody was raised against a 18 amino acid peptide from near the amino terminus of human DARC. (AP30274CP-N)
Isotype IgG
Specificity This antibody reacts to DARC.
Purification Affinity chromatography purified via peptide column
Alternative Name CD234 / DARC
Background DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.
Alternate names: Duffy antigen/chemokine receptor, FY, Fy glycoprotein, GPD, Glycoprotein D, GpFy, Plasmodium vivax receptor
Gene ID 2532
NCBI Accession Q16570
UniProt Q16570
Application Notes ELISA. Western Blot: 1 – 2 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Gil, Vita, Lebel-Binay et al.: "A member of the tetra spans transmembrane protein superfamily is recognized by a monoclonal antibody raised against an HLA class I-deficient, lymphokine-activated killer-susceptible, B lymphocyte line. Cloning and preliminary functional studies." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 9, pp. 2826-33, 1992 (PubMed).

Chaudhuri, Polyakova, Zbrzezna et al.: "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 22, pp. 10793-7, 1993 (PubMed).

Gardner, Patterson, Ashton et al.: "The human Duffy antigen binds selected inflammatory but not homeostatic chemokines." in: Biochemical and biophysical research communications, Vol. 321, Issue 2, pp. 306-12, 2004 (PubMed).

Validation Images
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