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serine/threonine Kinase 17a (STK17A) (N-Term) antibody

Details for Product No. ABIN499768
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Antigen
Synonyms STK17A, DRAK1, RDRAK1
Epitope
N-Term
(16), (6), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(69), (15), (13), (1), (1), (1)
Host
Rabbit
(56), (11), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(56), (26), (10), (9), (9), (4), (4), (3), (2), (2), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN499768
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Immunogen Human DRAK1 (N-Terminus) Peptide (AP30302CP-N)
Isotype IgG
Specificity DRAK1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DRAK1. DRAK1 antibody has no cross responses to DRAK2, DAP or ZIP kinases.
Purification Affinity chromatography purified via peptide column
Alternative Name STK17A / DRAK1
Background Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis- inducing protein kinases (1). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues (1).
Alternate names: DAP kinase-related apoptosis-inducing protein kinase 1, Serine/threonine-protein kinase 17A
Gene ID 9263
NCBI Accession Q9UEE5
UniProt Q9UEE5
Application Notes ELISA. Western Blot: 0.5 – 1 μg/ml. A431 or MOLT4 whole cell lysate can be used as positivecontrol and an approximately 50 kDa band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Sanjo, Kawai, Akira: "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 29066-71, 1998 (PubMed).

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