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Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Intermediate Domain) antibody

Details for Product No. ABIN499883, Supplier: Log in to see
  • AU042498
  • glial cell line derived neurotrophic factor family receptor alpha 1
  • GDNF family receptor alpha 1
  • Gfra1
Intermediate Domain
Human, Mouse (Murine), Rat (Rattus)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Immunogen Human GFR alpha 1 (Intermediate Domain) Peptide
Isotype IgG
Specificity GFR alpha 1 antibody was raised against a peptide corresponding to amino acids 369 to 382 of human GFR alpha 1.
Purification DEAE Chromatography
Alternative Name GFRA1 / GDNFR-alpha (GFRA1 Antibody Abstract)
Background Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1
Gene ID 2674
UniProt P56159
Application Notes ELISA. Western Blot. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Intermediate Domain) antibody (ABIN499883) Immunohistochemistry of GFR alpha 1 in human brain tissue with GFR alpha 1 antibody a...
Western Blotting (WB) image for anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Intermediate Domain) antibody (ABIN499883) Western blot analysis of GFR alpha 1 in crude membrane fractions of human brain (B), ...
Background publications Sanicola, Hession, Worley, Carmillo, Ehrenfels, Walus, Robinson, Jaworski, Wei, Tizard, Whitty, Pepinsky, Cate: "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6238-43, 1997 (PubMed).

Buj-Bello, Adu, Piñón, Horton, Thompson, Rosenthal, Chinchetru, Buchman, Davies: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

Jing, Wen, Yu, Holst, Luo, Fang, Tamir, Antonio, Hu, Cupples, Louis, Hu, Altrock, Fox: "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF." in: Cell, Vol. 85, Issue 7, pp. 1113-24, 1996 (PubMed).

Treanor, Goodman, de Sauvage, Stone, Poulsen, Beck, Gray, Armanini, Pollock, Hefti, Phillips, Goddard, Moore, Buj-Bello, Davies, Asai, Takahashi, Vandlen, Henderson, Rosenthal: "Characterization of a multicomponent receptor for GDNF." in: Nature, Vol. 382, Issue 6586, pp. 80-3, 1996 (PubMed).