Coiled-Coil Domain Containing 88A (CCDC88A) (C-Term) antibody

Details for Product No. ABIN499889
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Synonyms DKFZp459N1815, ccdc88a, MGC175202, A430106J12Rik, AI848406, Ape, C130096N06Rik, C330012F17Rik, D130005J21Rik, Girdin, Giv, Grdn, Hkrp1, GIV, RGD1306694, APE, GIRDIN, GRDN, HkRP1, KIAA1212
(22), (12), (9), (5), (3), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(79), (50), (31)
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(31), (30), (26), (22), (18), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN499889
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Immunogen Girdin antibody was raised against a 16 amino acid peptide from near the carboxy terminus human Girdin.
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name Girdin
Background Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development, depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.Synonyms: APE, Akt phosphorylation enhancer, CCDC88A, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, GIV, GRDN, Girders of actin filament, HkRP1, Hook-related protein 1, KIAA1212
Gene ID 55704
NCBI Accession NP_060554
UniProt Q3V6T2
Application Notes ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Background publications Lee, Guizar-Sicairos: "Validation of quantitative Ronchi test through numerical propagation." in: Optics express, Vol. 18, Issue 18, pp. 18525-31, 2010 (PubMed).

Enomoto, Asai, Namba et al.: "Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus." in: Neuron, Vol. 63, Issue 6, pp. 774-87, 2009 (PubMed).

Enomoto, Murakami, Asai et al.: "Akt/PKB regulates actin organization and cell motility via Girdin/APE." in: Developmental cell, Vol. 9, Issue 3, pp. 389-402, 2005 (PubMed).

Anai, Shojima, Katagiri et al.: "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis." in: The Journal of biological chemistry, Vol. 280, Issue 18, pp. 18525-35, 2005 (PubMed).

Le-Niculescu, Niesman, Fischer et al.: "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles." in: The Journal of biological chemistry, Vol. 280, Issue 23, pp. 22012-20, 2005 (PubMed).

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