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Details for Product No. ABIN500895

G Protein-Coupled Receptor 124 (GPR124) (C-Term) antibody

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Antigen
Synonyms Tem5, mKIAA1531, 8430414O08Rik, 9530074E10Rik, GPR124, TEM5, MGC69043, si:dkey-208c22.2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN500895
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen TEM5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human TEM5.
Isotype IgG
Specificity This antibody detects GPR124 / TEM5 at C-term.
Purification Peptide affinity chromatography
Alternative Name GPR124 / TEM5
Background Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
Alternate names: G-protein coupled receptor 124, KIAA1531, Tumor endothelial marker 5
Gene ID 25960
NCBI Accession Q96PE1
Research Area Cancer
Application Notes ELISA. Western blot: 1 – 2 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Cross, Lindsey, Fantes et al.: "The structure of a subterminal repeated sequence present on many human chromosomes." in: Nucleic acids research, Vol. 18, Issue 22, pp. 6649-57, 1991 (PubMed).

Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Yamamoto, Irie, Asada et al.: "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein." in: Oncogene, Vol. 23, Issue 22, pp. 3889-97, 2004 (PubMed).

Davies, Cunnick, Mansel et al.: "Levels of expression of endothelial markers specific to tumour-associated endothelial cells and their correlation with prognosis in patients with breast cancer." in: Clinical & experimental metastasis, Vol. 21, Issue 1, pp. 31-7, 2004 (PubMed).

Vallon, Essler: "Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34179-88, 2006 (PubMed).

Alternatives for antigen "G Protein-Coupled Receptor 124 (GPR124)", type "Antibodies"
Hosts (74)
Reactivities (74), (42), (35), (29), (29), (29)
Applications (27), (27), (25), (20), (19), (15), (5), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (9), (7), (5), (4), (4), (1)
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