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Details for Product No. ABIN502370

SH3 Domain Containing Ring Finger 1 (SH3RF1) (Middle Region) antibody

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Antigen
Synonyms POSH, RNF142, SH3MD2, Posh, R75531, Sh3md2, 2200003J05Rik, posh, rnf142, sh3md2, xPOSH, MGC135632, MGC189605
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN502370
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-SH3RF1 antibody: synthetic peptide directed towards the middle region of human SH3RF1
Sequence LLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVG PELPPGGGHG
Predicted Reactivity Guinea pig : 100%, Horse : 100%, Mouse : 100%, Rabbit : 100%, Rat : 100%, Dog : 92%, Pig : 92%, Chicken : 85%
Characteristics This is a rabbit polyclonal antibody against SH3RF1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name SH3RF1
Background SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Molecular Weight 93kDa
Gene ID 57630
NCBI Accession NP_065921, NM_020870
UniProt Q7Z6J0
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-SH3RF1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Lyons, Thorburn, Ryan et al.: "Regulation of the Pro-apoptotic scaffolding protein POSH by Akt." in: The Journal of biological chemistry, Vol. 282, Issue 30, pp. 21987-97, 2007 (PubMed).

Alternatives for antigen "SH3 Domain Containing Ring Finger 1 (SH3RF1)", type "Antibodies"
Hosts (18), (5)
Reactivities (22), (15), (14), (12), (12), (12)
Applications (13), (10), (10), (3), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (1)
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