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Sterol-C5-Desaturase (ERG3 delta-5-Desaturase Homolog, S. Cerevisiae)-Like (SC5DL) (N-Term) antibody

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Antigen
Synonyms ERG3, S5DES, SC5DL, A830037K02, A830073K23Rik, Sc5dl
Epitope
N-Term
(2)
Reactivity
Human
(3)
Host
Rabbit
(3)
Clonality
Polyclonal
Application
Western Blotting (WB)
(3), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human SC5DL
Blocking Peptide Blocking peptide for this product available: ABIN983415
Sequence NQVRREIKFT VQALPWISIL TVALFLLEIR GYSKLHDDLG EFPYGLFELV
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against SC5DL. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SC5DL (SC5DL Antibody Abstract)
Background SC5DL catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described.
Molecular Weight 35 kDa
Gene ID 6309
NCBI Accession NM_001024956, NP_001020127
UniProt O75845
Research Area Signaling, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 299 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Sterol-C5-Desaturase (ERG3 delta-5-Desaturase Homolog, S. Cerevisiae)-Like (SC5DL) (N-Term) antibody (ABIN502559) WB Suggested Anti-SC5DL Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Krakowiak, Wassif, Kratz et al.: "Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency." in: Human molecular genetics, Vol. 12, Issue 13, pp. 1631-41, 2003 (PubMed).

Catalog No. ABIN502559
$289.00
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