Heat Shock 70kDa Protein 4 (HSPA4) (Middle Region) antibody

Details for Product No. ABIN502697
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Antigen
Synonyms hs24/p52, hspa4-a, osp94, pg-2, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY, 70kDa, AI317151, Hsp110, Hsp70RY, mKIAA4025, Hsp70, irp94, hspa4, wu:fi30e11, zgc:55743, zgc:77413
Epitope
Middle Region
(3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Xenopus laevis, Zebrafish (Danio rerio), Pig (Porcine), Human, Chicken
(18), (6), (3), (3), (2), (1), (1), (1)
Host
Rabbit
(14), (6)
Clonality
Polyclonal
Application
Western Blotting (WB)
(19), (6), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN502697
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Immunogen Synthetic peptide directed towards the middle region of human HSPA4
Sequence PIKIRFQESE ERPKLFEELG KQIQQYMKII SSFKNKEDQY DHLDAADMTK
Predicted Reactivity Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Bovine : 90 %, African clawed frog : 80 %, Chicken : 80 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against HSPA4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HSPA4
Background HSPA4(Hsp70) belongs to the heat shock protein 70 family. It was isolated as a putative Rictor interacting protein and interaction with membranes acts as a platform for its release into the extracellular environment during its recovery from stress. Hsp70 gene expression in Rheumatoid Arthitis-affected synovial tissue is followed by Hsp70 cell surface expression on fibroblast-like synovial cells growing from RA synovial tissue. Serum Hsp70 levels were increased in Systemic sclerosis patients, and associated with pulmonary fibrosis, skin sclerosis, renal vascular damage, oxidative stress, and inflammation.
Molecular Weight 94 kDa
Gene ID 3308
NCBI Accession NP_002145, NM_002154
UniProt P34932
Research Area Heat Shock Proteins
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 840 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Heat Shock 70kDa Protein 4 (HSPA4) (Middle Region) antibody Host: Rabbit
Target Name: HSPA4
Sample Tissue: Human 721_B
Antibody Dilution: 1.0 µg/mL HSPA4 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells
Background publications Kim, Jiang, Du et al.: "PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1." in: Molecular cell, Vol. 30, Issue 2, pp. 239-47, 2008 (PubMed).

Validation Images
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