Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG5) (N-Term) antibody

Details for Product No. ABIN503664
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Synonyms EST1B, LPTS-RP1, LPTSRP1, SMG-5, BC024683, mKIAA1089, zgc:113841
(1), (1), (1)
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(5), (2), (2)
(5), (1)
Western Blotting (WB)
(6), (2), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN503664
Quantity 50 µg
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Immunogen Synthetic peptide directed towards the N terminal of human SMG5
Predicted Reactivity Bovine : 100 %, Human : 100 %, Horse : 90 %, Mouse : 90 %, Pig : 90 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against SMG5. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SMG5
Background SMG5 plays a role in nonsense-mediated mRNA decay. SMG5 does not have RNase activity by itself. SMG5 promotes dephosphorylation of RENT1. SMG5 is necessary for TERT activity.SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).
Molecular Weight 114 kDa
Gene ID 23381
NCBI Accession NM_015327, NP_056142
UniProt Q9UPR3
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 1016 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) (SMG5) (N-Term) antibody WB Suggested Anti-SMG5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
Background publications Glavan, Behm-Ansmant, Izaurralde et al.: "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex." in: The EMBO journal, Vol. 25, Issue 21, pp. 5117-25, 2006 (PubMed).

Hosts (5), (1)
Reactivities (5), (2), (2)
Applications (6), (2), (2), (1)
Epitopes (1), (1), (1)
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