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Details for Product No. ABIN504512

Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) (N-Term) antibody

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Antigen
Synonyms
AA986091, Arx, Sae2, UBA1, Ubl1a2, Uble1b, A1S9, A1S9T, A1ST, AMCX1, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X, Sbx, Ube-1, Ube1x, DDBDRAFT_0190927, DDBDRAFT_0220497, DDB_0190927, DDB_0220497, a1s9, a1s9 ... show more
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN504512
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-UBA1 antibody: synthetic peptide directed towards the N terminal of human UBA1
Sequence MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEP GRHPQAVAAV
Predicted Reactivity Bovine : 100%, Dog : 100%, Horse : 100%, Human : 100%, Mouse : 100%, Pig : 100%, Rabbit : 100%, Rat : 100%
Characteristics This is a rabbit polyclonal antibody against UBA1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name UBA1
Background UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
Molecular Weight 116kDa
Gene ID 7317
NCBI Accession NP_003325, NM_003334
UniProt P22314
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-UBA1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Ramser, Ahearn, Lenski et al.: "Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy." in: American journal of human genetics, Vol. 82, Issue 1, pp. 188-93, 2008 (PubMed).

Alternatives for antigen "Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1)", type "Antibodies"
Hosts (27), (3)
Reactivities (28), (8), (5), (2), (2)
Applications (29), (15), (10), (9), (5), (2), (1), (1), (1)
Epitopes (5), (3), (3), (1), (1), (1), (1)
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