Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) (N-Term) antibody

Details for Product No. ABIN504512
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Antigen
Synonyms
DDBDRAFT_0190927, DDBDRAFT_0220497, DDB_0190927, DDB_0220497, a1s9, a1s9t, a1st, amcx1, gxp1, poc20, smax2, uba1a, ube1, ube1x, uba1, uba1b, ube, zgc:66143, wu:fa01e08, wu:fb30f01, wu:fi21c11, wu:fj14 ... show more
DDBDRAFT_0190927, DDBDRAFT_0220497, DDB_0190927, DDB_0220497, a1s9, a1s9t, a1st, amcx1, gxp1, poc20, smax2, uba1a, ube1, ube1x, uba1, uba1b, ube, zgc:66143, wu:fa01e08, wu:fb30f01, wu:fi21c11, wu:fj14g11, A1S9, A1S9T, A1ST, AMCX1, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X, Sbx, Ube-1, Ube1x, AA986091, Arx, Sae2, UBA1, Ubl1a2, Uble1b show less
Epitope
N-Term
(12), (9), (9), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
(49), (10), (8), (2), (2)
Host
Rabbit
(44), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(46), (30), (22), (11), (7), (5), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN504512
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human UBA1
Sequence MEAGPPGSAR PAEPGPCLSG QRGADHTASA SLQSVAGTEP GRHPQAVAAV
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against UBA1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name UBA1
Background UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
Molecular Weight 116 kDa
Gene ID 7317
NCBI Accession NP_003325, NM_003334
UniProt P22314
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1058 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) (N-Term) antibody WB Suggested Anti-UBA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: HepG2 cell lysate
Background publications Ramser, Ahearn, Lenski et al.: "Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy." in: American journal of human genetics, Vol. 82, Issue 1, pp. 188-93, 2008 (PubMed).

Validation Images
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